| Achievement | How to unlock
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| - Unlock all diseases in one system.
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| - Evolve the Athlete Lifestyle.
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| - Reach 100% Recovery while patient health is 60% or higher at lethal difficulty.
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| - Complete all Death and Life stages at lethal difficulty.
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| - Perform 3 or more diagnostic tests simultaneously.
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| - Have your victim's circulatory system collapse first.
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| - Win a game at 95% recovery or more.
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| - Complete all Life stages.
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| - Complete all Death and Life stages.
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| - Finish a stage with 200% Diagnosis efficiency or more.
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| - Identify 5 diseases or more using a single test.
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| - Identify 3 diseases or more using a single test.
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| - Have your victim's digestive system collapse first.
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| - Reach 100% Recovery while patient health is 60% or higher.
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| - Perform 4 or more operations in a single game.
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| - Lose a patient at 90% Recovery or more.
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| - Have your victim's Immune system collapse first.
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| - Reach 100% Recovery while patient health is 5% or below.
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| - Win a game before the recovery reaches 70% at Lethal difficulty.
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| - Start a game with 5 boosters.
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| - Complete at least one tutorial.
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| - Have your victim's muscular system collapse first.
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| - Have your victim's nervous system collapse first.
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| - Reach 100% recovery before patient is sent to emergency room.
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| - Cause a Strike while in Emergency Room.
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| - Evolve 6 or more Lifestyles items.
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| - Treat 3 or more diseases simultaneously.
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| - Complete all Death stages.
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| - Have your victim's renal system collapse first.
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| - Have your victim's respiratory system collapse first.
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| - Collect 250 Bio Points or more in a game.
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| - Evolve 6 or more diseases before the recovery has started.
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| - Have your victim's skeletal system collapse first.
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| - Use an intensive care operation or lifestyles to get your patient out of the emergency room.
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| - Stack 30 Bio Points before spending anything.
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| - Win a game before the recovery reaches 70%.
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