| Achievement | How to unlock
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| - Beat Level 20 in 20 seconds or less.
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| - Activate 30 powerups in a single playthrough.
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| - Unlock all 4 challenge modes.
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| - Get an S rank on the Acceleration challenge.
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| - Get to level 75 from level 1 with no powerups equipped.
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| - Switch colors 256 times in a single level...with one eye closed.
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| - Unlock all of the music in Intake.
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| - Fill the powerup bar with alternating colored kills!
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| - Clear the screen with a Monochrome powerup and then again with the opposite color Monochrome.
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| - Get a Rainbow Bonus with the Lightning powerup.
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| - Kill 10 pills while flashbanged.
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| - Kill 10 Flashbangs in a single level.
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| - Kill 20 tablets while in between levels.
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| - Buy something from the Drugstore.
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| - Kill 20 pills with the shield in a single playthrough.
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| - Tabletize a powerup when the level ends.
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| - Have a 100-pill-long combo.
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| - Complete all 4 challenge modes.
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| - Beat a level while 5 pills are below the shield line.
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| - Kill 10 bombs with the shield in a single level past 50 without losing a life or detonating a bomb yourself.
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| - Kill all the tablets in two back-to-back level end tablet rainbows.
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| - Detonate a bomb to kill more pills than you need to finish the level.
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| - Perfectly clear an Acceleration level above level 50.
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| - Chain 4 Slow Mo powerups in a row.
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| - Kill 20 bombs with the shield in a single level past 50 without losing a life or detonating a bomb yourself.
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| - Flash yourself by hitting a flashbang.
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| - Get an S rank on the Flood challenge.
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| - Kill all of the tablets in Tablet Frenzy.
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| - Beat level 75 with no powerups equipped, without losing combo or dying.
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| - Get 50 Rainbow Bonuses in a single playthrough.
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| - Have five lives, then get a life overfill bonus.
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| - Kill 7 other pills with a single bomb.
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| - Beat Will's score of 30 million. Rub it in his face. @willstall
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| - Kill 10 pills after they've passed through the shield in a single playthrough.
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| - Beat the game without losing a life and without breaking your combo.
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| - Earn an extra life and lose it again within one second.
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| - Beat the game starting at level 1 with no powerups equipped, and without losing a life.
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| - Have a 1000-pill-long combo.
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| - Get an S rank on the Minefield challenge.
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| - Tabletize 10 powerups in a single playthough.
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| - Buy EVERYTHING in the Drugstore
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| - Set your starting level to something higher than level 1.
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| - Kill 10 pills while Embiggened.
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| - Beat a level without ever changing color.
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| - Beat the game without losing a life.
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| - Kill 100,000 total pills.
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| - Beat the game with only the Monochrome powerup equipped.
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| - Post a score on the high score board.
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| - Have Embiggening, Invincibility, and Slo Mo active at the same time.
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| - Kill 10 pills before they become visible on the screen in a single playthrough.
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| - Beat the game from level 1 with no powerups equipped.
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| - Kill all 12 tablets in the level end tablet rainbow.
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| - Get an S rank on the Reaction Challenge.
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| - Fill your powerup bar 1000 times.
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| - Kill a bomb without destroying anything else.
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| - Kill 3 pills in 0.3 seconds or less.
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| - Switch colors a total of 10000 times.
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| - Kill 3 pills, switch colors 3 times, and then kill 3 more pills.
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| - Kill 20 pills while in Slow Mo.
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| - Deploy a Lightning powerup when there's nothing on screen.
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| - Deploy a Monochrome powerup and have it kill no pills.
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| - Get 12 life overfill bonuses.
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| - Get a 300 Combo, then lose it.
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| - Kill 20 or more pills with a single Lightning powerup.
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| - Go through a Minefield level without setting off a Flashbang.
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| - Kill 20 pills while invincible.
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| - Unlock all the colors Intake has to offer!
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| - Max out a product in the Drugstore.
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| - Have a 500-pill-long combo.
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| - Kill 30 pills with the shield in an Acceleration level without dying.
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| - Flash yourself 5 times past level 50 in a single playthrough.
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