| Achievement | How to unlock
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| 20 / 20 | Beat Level 20 in 20 seconds or less.
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| 30 Pieces of Silver | Activate 30 powerups in a single playthrough.
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| A New Challenger | Unlock all 4 challenge modes.
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| Acceleration Master | Get an S rank on the Acceleration challenge.
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| Addict | Play 1000 games.
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| Almost There | Get to level 75 from level 1 with no powerups equipped.
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| Arr Gee Bee | Switch colors 256 times in a single level...with one eye closed.
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| Audiophile | Unlock all of the music in Intake.
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| Barbershop | Fill the powerup bar with alternating colored kills!
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| Bichromial | Clear the screen with a Monochrome powerup and then again with the opposite color Monochrome.
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| Bifrost | Get a Rainbow Bonus with the Lightning powerup.
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| Big Pharma | Earn 1 million total MG.
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| Blind Fury | Kill 10 pills while flashbanged.
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| Blinded By The Light | Kill 10 Flashbangs in a single level.
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| Can't Stop Won't Stop | Kill 20 tablets while in between levels.
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| Capitalist | Buy something from the Drugstore.
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| Captain America | Kill 20 pills with the shield in a single playthrough.
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| Cash For Gold | Tabletize a powerup when the level ends.
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| Centurion | Have a 100-pill-long combo.
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| Challenge Accepted | Complete all 4 challenge modes.
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| Checkpoint 25 | Reach Level 25
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| Checkpoint 50 | Reach Level 50.
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| Checkpoint 75 | Reach Level 75
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| Cutting It Close | Beat a level while 5 pills are below the shield line.
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| Defuser | Kill 10 bombs with the shield in a single level past 50 without losing a life or detonating a bomb yourself.
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| Double Rainbow | Kill all the tablets in two back-to-back level end tablet rainbows.
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| Escape Velocity | Detonate a bomb to kill more pills than you need to finish the level.
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| Ex-Speed-Ient | Perfectly clear an Acceleration level above level 50.
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| Exceeding Dosage | Chain 4 Slow Mo powerups in a row.
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| Expert Defuser | Kill 20 bombs with the shield in a single level past 50 without losing a life or detonating a bomb yourself.
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| Flashbang | Flash yourself by hitting a flashbang.
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| Flood Master | Get an S rank on the Flood challenge.
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| Fully Medicated | Kill all of the tablets in Tablet Frenzy.
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| Getting There | Beat level 75 with no powerups equipped, without losing combo or dying.
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| Gold At The End | Get 50 Rainbow Bonuses in a single playthrough.
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| Heart Attack | Have five lives, then get a life overfill bonus.
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| Ka-Plooey | Kill 7 other pills with a single bomb.
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| King of the Will | Beat Will's score of 30 million. Rub it in his face. @willstall
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| Last Second Savior | Kill 10 pills after they've passed through the shield in a single playthrough.
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| Literally Awesome | Beat the game without losing a life and without breaking your combo.
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| Loved and Lost | Earn an extra life and lose it again within one second.
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| Masocore | Beat the game starting at level 1 with no powerups equipped, and without losing a life.
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| Millenium | Have a 1000-pill-long combo.
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| Minefield Master | Get an S rank on the Minefield challenge.
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| Monetization | Tabletize 10 powerups in a single playthough.
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| Monopoly | Buy EVERYTHING in the Drugstore
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| Moving On Up | Set your starting level to something higher than level 1.
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| Mushroom Madness | Kill 10 pills while Embiggened.
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| Never Change | Beat a level without ever changing color.
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| One Man Army | Beat the game without losing a life.
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| Pharmassacre | Kill 100,000 total pills.
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| Playing Favorites | Beat the game with only the Monochrome powerup equipped.
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| Points on the Board | Post a score on the high score board.
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| Power Overwhelming | Have Embiggening, Invincibility, and Slo Mo active at the same time.
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| Precog | Kill 10 pills before they become visible on the screen in a single playthrough.
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| Pure Play | Beat the game from level 1 with no powerups equipped.
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| Rainbow | Kill all 12 tablets in the level end tablet rainbow.
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| Reaction Challenge | Get an S rank on the Reaction Challenge.
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| Real Ultimate Power | Fill your powerup bar 1000 times.
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| Remote Detonation | Kill a bomb without destroying anything else.
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| Sharpshooter | Kill 3 pills in 0.3 seconds or less.
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| Shifting Sands | Switch colors a total of 10000 times.
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| SOS | Kill 3 pills, switch colors 3 times, and then kill 3 more pills.
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| Speeding Bullet | Kill 20 pills while in Slow Mo.
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| Static Electricity | Deploy a Lightning powerup when there's nothing on screen.
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| Swing and a Miss | Deploy a Monochrome powerup and have it kill no pills.
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| The Doctor | Get 12 life overfill bonuses.
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| THIS IS SPARTA | Get a 300 Combo, then lose it.
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| Thor's Hammer | Kill 20 or more pills with a single Lightning powerup.
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| Tread Lightly | Go through a Minefield level without setting off a Flashbang.
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| Unbreakable | Kill 20 pills while invincible.
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| Unstoppable | Beat the game!
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| Vanity | Unlock all the colors Intake has to offer!
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| Vertical Integration | Max out a product in the Drugstore.
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| Walk 500 Miles | Have a 500-pill-long combo.
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| Weather the Storm | Kill 30 pills with the shield in an Acceleration level without dying.
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| Wild Trip | Flash yourself 5 times past level 50 in a single playthrough.
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