If you have a lot of money, and have unlocked a particular gun, you can buy that gun and sell it for a very reduced price. However, when you sell the gun, whatever ammunition inside it when being sold is be transferred to your inventory, allowing you to "buy" ammo, albeit at a very high price Note: Buy the lowest cost type of gun because the ammunition is universal. For example, it does not matter which pistol to buy, as long as you are trying to get pistol ammunition.
Devil May Cry 2 reference
The name for the virus in Resident Evil 5, Uroboros, is also used as a name for the corporation in Devil May Cry 2, another Capcom game.
Easy "Be the Knife" achievement
Play Stage 2-1 solo. Disarm the AI partner and stock her with first aid. Immediately after leaving the warehouse, you will walk between two container stacks and two Majini enemies with crossbows will spawn above you. Kill the Majini that is closer to the crates, and not the ocean. The Majini closer to the ocean is who you will be trying to hit a crossbow shot away. Try and line up with him from your position on the ground, and move a slightly to the left so he becomes slightly off-center from you. If positioned correctly, when he shoots he will be aiming directly at your feet and missing. Once you are positioned correctly, take out your knife and time your swing. Hit his arrow when he fires it. He will need a few seconds before firing again after reloading because he will stare at you.
Easy "Heart Stopper" achievement
Play Chapter 5-1 as Chris or Sheva under the easy difficulty setting and encounter the first Licker. Fire a shotgun at point blank range until it falls over on its back, and the quick time event icon appears to perform a finishing move. You will stab them in the heart with a knife. You must within melee range for the icon to appear. This may require a few attempts and more than one shotgun blast.
This trick will help you gain money to max out and buy all the weapons. In any chapter, collect as much gold, items, ammunition, and treasure you can find. When you are satisfied, pause game play and quit the game. Save the game when prompted. Restart any desired chapter. The "Shop" menu will appear before the start of any chapter. Notice that all the gold, treasure, weapons, and ammunition from your previous saved game are still in your inventory. From there, you can sell anything you want to gain some fast cash. This glitch can be done repeatedly, on any chapter.
Go through a chapter, collecting as many hand grenades as possible. Then, start Co-op mode with a friend, system link, or over the Internet. Give your partner all of your grenades and have them exit the game. After they leave, your AI partner will still have all of the grenades. Make sure you request them back. While you do this, your friend that left can sell the ones he took with him. You can have up to five in each slot, and they sell for 250 gold each. You will gain 11,322 gold each time you do this (if you have all your slots full). This is also a good way to stock up on ammunition.
As soon as you defeat the Uruoburos for the second time you can repeat the beginning of that chapter and collect lots of money and ammunition (especially for the machine gun). Repeat this several times and you will be able to upgrade every weapon in your arsenal.
Once you have completed the game, go to Chapter 5-1 (Underground Garden). Bring extra ammunition if possible. Follow the chapter until you have reached the part with all the Lickers. Do not press the button to the elevator yet. Kill all the Lickers that are there, then gather all the treasures and money they dropped. Press the button to the elevator. When you do this, about four or five more Lickers will appear. Also kill them. Once again, gather the treasures. Then, quit the game and repeat until satisfied. You should make about 10,000 gold selling the treasures the Lickers drop. There are no enemies except for the Lickers you are meant to defeat, which will make for easy money for weapon upgrades.
The best way to stockpile gold for upgrades is to replay the beginning of Chapter 4-1. Start by running forward en route to the cave entrance. Once in the cave, run forward and a cinematic will play, introducing the Bui Kichwa spiders. These can be taken out swiftly with a flash grenade, but are also easy enough to plow through with a pistol and/or knife. Dispatch the first few spiders you see, then run past the ladder and into the small room at the back. Run to the vase, turn around, and look up to shoot a gem off the ceiling. Also, grab the gem from the chest. Backtrack and go up the ladder. Take out the spider then proceed onwards down the winding cave. Just past the first few vases, knife the standing torch for a gem. After taking out a slew of spiders, proceed forward and knife the ground torch for another gem. When you reach the bottom there are three gems to be found. One is in the skull on the right. The other two are on the left-hand side; one in the standing torch, and one on the ground in a skull. This takes about four minutes and yields 8,000 gold in gems, plus an additional 2,000 gold if a Bui Kichwa drops a rotten egg. You should also pick up a variety of ammo and grenades after doing this for awhile, so it is well worth your time. Additionally, you may continue forward through the door at the bottom of the cave. If you choose to, then do as follows. Run forward and jump down. Shoot at the wall over the entrance to the next room for a gem. Keep moving until you find a tomb that you can open for 900 gold. In the next room, knife the lantern for a gem. Proceed forward for a cinematic. After that, drop down and mow through all the Majini in your path, stopping for another gem found in the ground torch behind the masked Majini with a crossbow. After taking care of the shielded Majinis, walk into the first room and collect two gems and 700 gold from the tomb. In the next room, grab the gem from the ground torch and the one held by a mummy. Once you fall down the trick tomb, take care of the Bui Kichwa and the Majini who appear, then retrieve the three gems from the chests. Quit after this point if you came this far. This half of the trek yields 12,000 gold in gems plus additional gold, ammo, grenades, herbs, etc. found along the way. It usually takes seven to eight minutes to do this. Note: It can be annoying to keep fighting all the Majini; you can choose to only follow the first part before repeating.
Start the Marshlands chapter and go up to the body of the dead soldier. Ignore the slate and pick up the beetle on the wall, the ruby in the mask, and the barrel contents. Then visit the following locations in no particular order: the island hut full of chickens, sinking boat, triangle huts, and village. At the chicken island, collect some eggs, the treasure in the house, and the barrel contents on the lookout. At the sinking boat, get the barrel and the rocket launcher. At the triangle huts, get the other beetle, the barrel contents, and the treasure on the lookout. There is also an insignia near the ceiling to shoot. At the village, get the emerald and all the barrels and jars. There is also a ruby in a mask on a post near a hut and the treasure. Do not get any slate pieces. Quit and go to "Item Management". Sell the treasures, eggs, and anything else that you do not need. Put the rocket launcher in storage and repeat the process until you are wealthy and have plenty of rocket launchers to make the boss battles easier. Use the money to level up your weapons. You can get roughly 15,000 gold each time. If you need to stock up on machine gun bullets, do the same thing in the Chapter 2-1 storage room. A blue insignia is also there. In the Caves, you can use your rocket launcher to take out the bat Boss. You will get a green gem worth 10,000 gold, which when added to all the other cave treasure, can increase your money dramatically.
Use the following trick to get a combined clear time for the entire game of under five hours (to unlock unlimited RPG ammunition). A really easy way of doing this is to play under the Amateur difficulty setting and just run pass all enemies. Only kill story-driven enemies (ones that hold key cards or those that must be defeated to advance the game). Also, avoid any crates, barrels, or treasures. Attempting this with a friend instead of the CPU-controlled Sheva is recommended. Note: You do not need to purchase the infinite ammo in "Bonus Features" as you would do for normal guns.
Efficient ammo, grenade, and herb farming
Start Chapter 6-2 with only the bare essentials you need to survive. It is recommended that you only bring one good handgun or shotgun weapon (for example, fully upgraded M92F, Jailbreaker -- because ammo will be more than plentiful) each for Chris and Sheva. If you feel you are proficient enough with your chosen weapon, you can take only one weapon for your chosen player and leave the other character's inventory completely empty so they can carry ammo and herbs. Get through the cutscene and interactive sequence. Once inside the tanker, scavenge any ammunition and herbs you can find. Do not forget the two chalices in the lockers for extra money. Once you are ready, head out to fight the Uroboros that Excella has now become. Do not finish her off until you have filled your bags with all the ammo and herbs you can carry. Begin by shooting the orbs on the ends of the tentacles until they are gone. This will prompt the Boss to start shooting small Uroboros creatures at you and your partner. Stay on the lower level (where the satellite aiming gun is located) so that you can command your partner to quickly pick up ammo. Begin shooting the small spawns the Boss is tossing at you, and each one will randomly drop some sort of item. It is best to separate the types of ammo each person picks up. For example, have Chris collect all the shotgun and pistol ammo while Sheva gets all the grenades and herbs, etc. This will help maximize space in your inventories and allow you manage the space efficiently. Repeat this process and dodge the Boss attacks (they are indicated by a context menu), and shoot the small spawns to keep collecting ammo and herbs. They commonly drop handgun and shotgun ammo and plenty of herbs and incendiary and hand grenades. Doing this for about five to ten minutes will net a large amount of ammo and herbs because the Boss will continuously spawn the small monsters until it is defeated. Once you are satisfied with your farming run, finish off the Boss through whatever means you desire and finish the episode for some quick exchange points. As long as you do not die and keep your firing accuracy up, it should be an easy "S" rank on practically any difficulty. Repeat the entire process if desired.
If both players stand in front each other and one of them heals themselves, both persons will get healed.
Use a weak weapon, such as a pistol. Shoot a Majini in the shin. If it bends over holding its knee, then run close beside it until you see the command "Neck Breaker". Note: With Sheva the command will be "Throat Slit". As soon as you see this command, press Square PlayStation3 or X Xbox 360 and it should result in an instant kill with one shot of the pistol. You can do this with multiple characters in Mercenaries mode for a one hit kill.
Complete the following achievements to unlock Xbox Live Gamerscore points.
Achievement | How to unlock | Points
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| - Defeat 5 enemies with the Knife.
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| - Save partner 10 times when HELP is displayed.
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| - Purchase all available alternative costumes in Bonus Features.
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| - During the first fight with Wesker, damage him a set number of times.
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| - Find all the BSAA emblems.
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| - Defeat 3 Majini at once with a drum or gas tank explosion.
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| - Deflect a bow gun arrow with your knife.
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| - Defeat 30 enemies with the Longbow.
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| - Defeat 30 enemies with the Stun rod.
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| - Complete Chapter 1 - 1 on any difficulty setting.
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| - Complete Chapter 1 - 2 on any difficulty setting.
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| - Complete Chapter 2 - 1 on any difficulty setting.
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| - Complete Chapter 2 - 2 on any difficulty setting.
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| - Complete Chapter 2 - 3 on any difficulty setting.
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| - Complete Chapter 3 - 1 on any difficulty setting.
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| - Complete Chapter 3 - 2 on any difficulty setting.
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| - Complete Chapter 3 - 3 on any difficulty setting.
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| - Complete Chapter 4 - 1 on any difficulty setting.
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| - Complete Chapter 4 - 2 on any difficulty setting.
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| - Complete Chapter 5 - 1 on any difficulty setting.
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| - Complete Chapter 5 - 2 on any difficulty setting.
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| - Complete Chapter 5 - 3 on any difficulty setting.
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| - Complete Chapter 6 - 1 on any difficulty setting.
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| - Complete Chapter 6 - 2 on any difficulty setting.
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| - Complete Chapter 6 - 3 on any difficulty setting.
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| - Defeat 30 enemies with the Gatling gun.
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| - Stop an armored truck by taking out the driver.
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| - Find all 4 types of eggs.
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| - Defeat a Majini with a rotten egg.
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| - Shoot an enemy Molotov cocktail, dynamite stick, or hand grenade.
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| - Defeat 20 enemies with physical attacks.
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| - Defeat 2 enemies with one flash grenade.
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| - Defeat a certain enemy by stabbing it in the heart.
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| - Defeat a Majini with a headshot while it's jumping.
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| - Save partner 10 times when DYING is displayed.
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| - Work together to save someone special.
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| - Defeat 3 Majini with one grenade or proximity bomb.
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| - Complete all chapters on Amateur.
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| - Defeat a Majini using the electric current from a transformer.
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| - Complete all chapters on Normal.
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| - Obtain all available weapons.
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| - Defeat 3 Majini at once by setting oil canisters on fire.
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| - Completely upgrade all weapons.
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| - Chain the maximum number of combos together in one go.
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| - Obtain all treasures in the game.
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| - Collect all the figurines.
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| - Complete all chapters on Veteran.
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| - Complete all chapters on Professional.
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| - Build up a certain level of trust with your partner.
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In addition to fully upgrading these weapons, you must also purchase the unlockable weapons from the Item Management Menu.
Unlockable | How to unlock
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| - Fully Upgrade VZ61 Machine Gun.
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| - Fully Upgrade M93 Shotgun.
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| - Fully Upgrade M92F Handgun.
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| - Fully Upgrade S&W M29 Magnum.
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