| Achievement | How to unlock
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| - Complete all Lavalands missions.
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- Amoebacide Denied (20 points)
| - Complete Mission 7 on Normal difficulty without using the Poison Probe.
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- Battle Royale (100 points)
| - Complete the Final mission.
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- Belly of the Beast (10 points)
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- Belongs in a Museum (15 points)
| - Complete Mission 5 on Normal difficulty without allowing the Analysis Probe to take damage.
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| - Complete Mission 5 on Normal difficulty without allowing more than 5 cysts to hatch.
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- Brutal Legend (60 points)
| - Complete the campaign on Brutal difficulty.
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- Damage Sponge (30 points)
| - Complete Mission 12 on Normal difficulty without allowing the Proteus Cyst to take damage.
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- Death From Above (10 points)
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- Feed and Multiply (10 points)
| - Complete Mission 1 on Normal difficulty with at least 10 amoebas alive.
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- Fight in the Shade (15 points)
| - Complete Mission 4 on Normal difficulty without replicating more than 15 times.
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- For Queen and Country (10 points)
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- Give in to Your Anger (25 points)
| - Complete Mission 6 on Normal difficulty by killing at least 60% of the enemy amoebas yourself.
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- God Save the Queen (25 points)
| - Complete Mission 10 on Normal difficulty without allowing the Queen to take damage.
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- If You Can't Beat 'Em (30 points)
| - Complete Mission 10 on Normal difficulty by purifying at least 50% of the Ursas.
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- Micro Manager (15 points)
| - Complete Mission 2 on Normal difficulty without losing a single amoeba.
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| - Complete Mission 11 on Normal difficulty with at least 10 amoebas alive.
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- Mitochondrawhat? (10 points)
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- Natural Selection (10 points)
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- Nipped in the Bud (10 points)
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- No Air Support (25 points)
| - Complete Mission 8 on Normal difficulty without using meteors to kill Alphas.
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- No One Left Behind (20 points)
| - Complete Mission 7 on Normal difficulty without losing any units to the Chaos Amoeba.
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- No Probe, No Problem (15 points)
| - Complete Mission 3 on Normal difficulty without using the Cryo Probe.
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- Patience Is a Virtue (25 points)
| - Complete Mission 6 on Normal difficulty without losing a single amoeba.
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- Primordial Supremacy (40 points)
| - Complete Mission 12 on Normal difficulty without deploying a single probe.
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- Return to Normalcy (20 points)
| - Complete the campaign on Normal difficulty.
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- Rumble in the Reef (10 points)
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- Save the Forest (40 points)
| - Complete all Mushroom Forest missions.
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- Shaken, Not Stirred (25 points)
| - Complete Mission 9 on Normal difficulty by eliminating all enemy amoebas.
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- Stretched Thin (15 points)
| - Complete Mission 3 on Normal difficulty without replicating.
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- Tactical Espionage Alpha (10 points)
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- The Bear Necessities (40 points)
| - Complete Mission 11 on Normal difficulty without mutating or purifying any amoebas.
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- The Few, the Proud (10 points)
| - Complete Mission 8 on Normal difficulty without replicating.
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- The Sweet Sixteen (10 points)
| - Complete Mission 2 on Normal difficulty without replicating more than 16 times.
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- There Can Be Only One (25 points)
| - Complete Mission 9 on Normal difficulty without replicating.
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- Under the Sea (60 points)
| - Complete all Primordial Sea missions.
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- Veteran Scars (40 points)
| - Complete the campaign on Veteran difficulty.
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- You Shall Not Pass (10 points)
| - Complete Mission 4 on Normal difficulty without letting an amoeba escape.
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