Certain character combinations unlock special boosts.
Boost | How to unlock
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| - Captain America, Nick Fury, Spider-Woman, Wolverine
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- Agile Warriors: 10% Reduced Energy Cost
| - Spider-Man, Spider-Woman, Elektra, Deadpool
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| - Human Torch, Ms. Marvel, Storm, Thor
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| - Ironman - War Machine, Ghost Rider Western, Spider-Woman - Secret Wars, Ms. Marvel Ventura, Thor - Beta Ray Bill
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| - Blade, Deadpool, Elektra, Wolverine
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| - Captain America, Thor, Iron Man, Spider-Woman, Ms. Marvel
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| - Blade, Ghost Rider, Luke Cage, Wolverine
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| - Thing, Captain America, Luke Cage, Ms. Marvel
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| - Black Panther, Captain America, Iron Man, Thor
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| - Blade, Elektra, Ghost Rider, Spider-Woman
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| - Dr. Strange, Iceman, Luke Cage, Silver Surfer
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| - Black Panther, Invisible Woman, Mr. Fantastic, Storm
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- Fantastic Four: 20 Health per KO
| - Mr. Fantastic, Invisible Women, Human Torch, Thing
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| - Ms. Marvel, Storm, Invisible Woman, Elektra, Spider-Woman
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| - Iceman in Snowy Form, Captain America in WW2, Daredevil in Original, Ghost Rider in Original, Iron Man in Classic, Orig. Ms. Marvel, Classic Wolverine
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| - Black Panther, Captain America, Daredevil, Moon Knight, Nick Fury
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| - Black Panther, Daredevil, Dr. Strange, Luke Cage, Spider-Man, Moon Knight
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| - Black Panther, Dr. Strange, Thor, Storm
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- Natural Forces: 5% Dmg inflicted as Health Gain
| - Thor, Strom, Human Torch, Ice Man
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| - Captain America, Dr. Strange, Mr. Fantastic, Nick Fury, Storm
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- New Avengers: +5% All Resistances
| - Captain America, Luke Cage, Wolverine, Spider-Man, Spider-Woman
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| - Ghost Rider, Luke Cage, Spider-Man, Wolverine
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- Power Platoon: 20 Energy per KO
| - Silver Surfer, Iron Man, Ms. Marvel, Thor
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- Raven Ultimates: +6 body, strike and focus
| - Deadpool, Colossus, Moon Knight, Thing
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| - Blade, Dr. Strange, Ghost Rider, Thor
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- Think Tanks: +15% Max Health
| - Dr. Strange, Mr. Fantastic, Spider-Man, Iron Man
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| - Blade, Captain America, Deadpool, Elektra, Nick Fury
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| - Colossus, Iceman, Storm, Wolverine
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