| Achievement | How to unlock
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| - Complete a game in Stage 2.
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| - Complete a game with Hydra (Stage 1 or above)
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| - Install three Horns in a Brain.
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| - Complete a game with Wealth (Stage 1 or above)
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| - Link three different types of Offspring.
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| - Defeat a Boss while you have only 1 HP.
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| - Complete a game with Queen (Stage 1 or above)
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| - Upgrade three different projects to the maximum level in Culture Room.
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| - Complete a game with Rhinoceros (Stage 1 or above)
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| - Complete Wave 35 in Endless Mode.
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| - Complete games with ten different Prototypes
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| - Complete Stage 5 with three different Prototypes.
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| - Complete a game with Fate (Stage 1 or above)
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| - Complete a game with only one brain (Stage 1 or above)
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| - Complete a Wave without killing any monster.
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| - Complete a game with Cuckoo (Stage 1 or above)
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| - Complete a game in Stage 5.
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| - Complete a game with Nature (Stage 1 or above)
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| - Complete a game with Squander (Stage 1 or above)
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| - Complete a game in Stage 1.
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| - Complete a game with Stomy (Stage 1 or above)
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| - Complete a game with Hunk (Stage 1 or above)
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| - Link Limbs to four different Brains.
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| - Link ten Organs to a Brain.
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| - Link a Belly and a Poison Bag to the same Brain.
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| - Complete a game in Stage 3.
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| - Complete a game in Stage 4.
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| - Complete a game with Harmony (Stage 1 or above)
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| - Complete games with three different Prototypes
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| - Complete Wave 25 in Endless Mode.
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| - Defeat a Boss while you are buffed by Wings.
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| - Complete a game with Genius (Stage 1 or above)
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