| Achievement | How to unlock | Points
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| - Performed hundred hits combo as Wolverine.
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| - Knocked down three enemies affected by cosmic damage with a single Silver Surfer tackle.
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| - Vanquished Annihilus and his invasion force.
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| - Knocked Venom out from his frenzy.
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| - Found all Cosmic Cubes hidden within each stages.
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| - Defeated fifty enemies using Cosmic Ghost Rider's blasters.
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| - Freed Silver Surfer from insectoid influence.
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| - Revived Phoenix and stopped the wave from invading Earth.
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| - Trapped fifty enemies with Iron Man's Electro-Charge attack.
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| - Defeated fifty enemies with Nova's photon blasts.
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| - Defeated fifty enemies with Rocket's grenades.
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| - Completed all Stage Challenges.
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| - Knocked down three enemies while using Venom's smashing grab on another adversary.
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| - Defeated fifty enemies with Beta Ray Bill's Stormbreaker.
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| - Performed a 200 Hits combo.
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| - Hit four enemies while throwing a single opponent with She-Hulk.
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| - Defeated Thanos and cut the Wave's supplies.
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| - Unlocked all rewards from the Matrix.
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| - Maxed out a Superhero's Level.
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| - Performed fifty successful Team Assist.
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| - Deflected fifty projectiles with Captain America's shield.
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| - Rescued Phyla-Vell from Annihilus' grasp.
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| - Performed a team assist using Wolverine and Storm on Dark Phoenix.
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| - Performed fifty kinetic parries as Black Panther.
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| - Absorbed ten electric attacks and dealt it back to an enemy as Storm.
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| - Defeated fifteen enemies with Phoenix's Fire Dash and Air Attack.
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| - Performed fifty successful teleport strikes as Phyla-Vell.
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| - Completed the game with all characters.
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| - Triggered a full Team Special Attack with three other players.
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| - Completed the game in Multiplayer (local or online)
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| - Knocked down five enemies in a single swinging kick with Spider-Man.
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| - Completed a stage in Multiplayer (local or online)
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| - Reached Ultimate Team Level.
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| - Used a hero to defeat his own doppelganger.
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