| Achievement | How to unlock | Points
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| - Killed ten enemies with explosives.
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| - Completed the story on Classic difficulty.
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| - Performed thirty headshots.
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| - Jumped a car over fourty meters.
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| - Completed all Assassinations, earning at least a medal in each.
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| - Enzo killed the Spadaro holdouts.
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| - Infiltrated the villa without being seen.
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| - Completed the race in under eight minutes.
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| - Completed Playing with Fire.
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| - Drove at 120 km/h for at least fifteen seconds.
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| - Fixed a broken vehicle by using the crank.
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| - Enzo freed the counterfeiter.
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| - Performed all Special Actions five times with each knife.
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| - Enzo refused Tino's order to kill in cold blood.
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| - Killed Caccini before he reached the Salt Flats.
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| - Enzo and Isabella's story came to an end.
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- Rare Weapons Expert: Lupara
| - Killed twenty enemies with a Lupara.
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- Rare Weapons Expert: Modello
| - Killed twenty enemies with a Modello C96.
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- Rare Weapons Expert: Praecisione
| - Killed twenty enemies with a Praecisione.
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- Rare Weapons Expert: Pump-Action
| - Killed twenty enemies with a Pump-Action Shotgun.
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- Rare Weapons Expert: Repeater
| - Killed twenty enemies with a Repeater.
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- Rare Weapons Expert: Vendetti
| - Killed twenty enemies with a Vendetti.
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| - Cracked a safe without a combination.
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| - Completed all Standoffs, earning at least a medal in each.
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| - Killed twenty enemies with Knife Takedowns.
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| - Killed Mazzone without alerting his men.
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| - Completed all Races, earning at least a medal in each.
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| - Completed the collection.
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| - Bought all available cars from Pasquale.
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| - Completed the story on any difficulty.
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| - Reached the foreman's office without alerting the enemies.
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| - Enzo and Cesare killed L'Ombra.
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| - Eliminated ten cars while escaping the Tonnara.
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| - Completed the story on Hard difficulty.
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| - Defeated Don Torrisi without taking a single hit.
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