| Trophy | How to unlock
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| - First kill with a Gas Mine.
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| - First kill with a Mop Handle.
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- Congratulations ( Platinum )
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| - Stomped first Minion to death.
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- Darwin Would Be Proud ( Bronze )
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| - First kill with a Mannequin Arm.
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| - First kill with a Shovel.
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| - First kill with a Hatchet.
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- I Can Stop Anytime ( Silver )
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- It Was An Accident ( Bronze )
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- Just Experimenting ( Bronze )
| - Used Health Syringe for the first time.
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- Kill Or Be Killed ( Silver )
| - Killed a Collared Minion with a collar detonation.
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| - First kill with a Table Lamp.
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| - Stomped five Minions to death.
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| - First kill with a Syringe.
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- Say Hello To My Little Friend ( Bronze )
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- Sometimes It Sticks ( Bronze )
| - First kill with a Nail Bat.
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- Splitting Headache ( Bronze )
| - First kill with Scissors.
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| - First kill with a Scalpel.
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- Wait For The Boom ( Bronze )
| - First kill with an Explosive Mine.
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- Who Is The Jigsaw Killer? ( Bronze )
| - Find your first Patient File.
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| - First kill with a Stun Mine.
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- Would You Like To Know More? ( Bronze )
| - Find your first Asylum File.
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- You'll Need This Afterwards ( Bronze )
| - First kill with a Crutch.
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- You've Been Served ( Bronze )
| - First kill with a Table Leg.
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- You've Wasted Your Life ( Bronze )
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