|Trophy||How to unlock
- Lose any Story Mode level within 5 seconds.
- Get a combo-pop of 100 or more germs with one shot.
- Feverish Cleaning (Bronze)
- Complete a Story Mode level in under 30 seconds.
- Complete 20 different levels in a single run in Puzzle Mode.
- Complete all Story Mode levels.
- Mother of all Pops (Bronze)
- Pop a germ of size 25x or greater.
- Fire 50 germs in a single Story, Duel, or Arcade level.
- Win the 15th round in a Duel match against "The Germinator".
- Complete all Puzzle Mode levels.
- Collect all stars in Puzzle and Story Mode.
- Survive for 5 minutes or more in Arcade Mode.
- Finish any Puzzle level with a single shot.