| Achievement | How to unlock
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| - Get 2 extra lives at the same time.
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- Amok in the Ammunition Depot
| - Defeat the boss in the Ammunition Depot.
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| - Unlock all colors for Annie.
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| - Defeat the boss of the Flying Ship.
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- Battle on the Armored Train
| - Defeat the boss on the Armored Train.
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| - Get a x5 bonus with either Clint or Annie.
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| - Unlock all colors for Bullet.
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| - Beat the Desolation Canyon stage without dying.
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| - Defeat the boss of Carson City.
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| - Beat the Carson City stage without dying.
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| - Unlock all colors for Clint.
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| - Beat the Ammunition Depot stage without dying.
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| - Move Bullet to the top of the screen using the drone.
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| - Unlock all colors for Doris.
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| - Defeat the boss in the Gold Mine.
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| - Beat Single Player on Easy without using any continues.
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| - Beat Single Player on Hard with all characters without using any continues.
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| - Defeat the boss of the Underground.
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| - Have Doris charge up 7 grenades.
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| - Beat the Gold Mine stage without dying.
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| - Beat Single Player on Normal with all characters without using any continues.
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| - Beat Single Player on Easy with all characters without using any continues.
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| - Beat Single Player on Hard without using any continues.
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| - Beat the Flying Ship stage without dying.
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- Showdown in Desolation Canyon
| - Defeat the boss of Desolation Canyon.
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| - Beat Single Player on Normal without using any continues.
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| - Beat the Armored Train stage without dying.
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| - Beat the Underground stage without dying.
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- Wild Guns Reloaded Master
| - Beat the Final Fight stage without dying.
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