Legendary weapon effects are bonuses obtained by defeating certain Legendary enemies.
| Weapon | How to unlock
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| - Deal 50% increased damage against humans.
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| - Deal increased damage depending upon your damage resistance.
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| - Deal increased damage depending upon your health.
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| - Take 15% decreased damage while blocking or sprinting.
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| - Deal 50% more limb damage.
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| - Your targets frenzy with critical hits.
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| - Your bullets to explode on impact dealing 15 area of effect damage.
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| - Deal 50% increased damage against Mirelurks and bugs.
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| - Deal +10 cryo-damage and freeze targets with critical hits.
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| - Deal increased damage with each consecutive hit on the same target.
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| - Deal 50% increased damage against Ghouls.
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| - Deal 50% increased damage against animals.
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| - Set targets on fire for +15 damage.
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| - Deal double damage to full health targets.
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| - Deal +50 radiation damage.
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| - Deal increased damage depending upon the withdrawal effects.
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| - 20% chance to cripple targets' legs.
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| - Deal double damage with critical shots with critical meters refilling 15% faster.
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| - Heals targets instead of dealing damage to them.
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| - Deal 50% increased damage against Super Mutants.
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| - 75% faster movement speed while ADS.
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| - Deal increased damage at night and decreased damage during the day.
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| - Negate 30% of the target's damage resistance and energy resistance.
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| - Turn enemies into goo and add +10 points of energy damage.
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| - Poison targets for 10 seconds.
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| - Decrease Action Points cost by 25%.
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| - 25% increased rate-of-fire and 15% increased reload speed.
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| - Refill Action Points with critical hits.
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| - 15% decreased damage while static.
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| - Stagger enemies with each hit.
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| - When not in combat, increases VATS accuracy at the cost of increased Action Points.
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| - Deal 50% increased damage against robots.
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| - Shoot additional projectiles.
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| - Increases VATS hit chances, decreases Action Points cost by 25% and 40%.
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| - Deal 25% damage and limb damage with increasing recoil.
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| - Bleed target for +25 additional damage.
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