| Achievement | How to unlock | Points
|
|---|
| Adapt or Die | Defeat the Bruch. | 30
|
| Adept | Beat the game on Normal difficulty or higher. | 30
|
| Ancient Blood | Defeat Felicity D'Abano. | 85
|
| Best the Beast | Defeat Felicity D'Abano without using the HP dispenser. | 70
|
| Bio Friendly | Defeat The Parasiter without killing any of the minions. | 70
|
| Bleed You Out | Defeat the Bruch without letting it heal. | 70
|
| Boys'n'Toys | Have all Weapon Upgrades activated at the same time. | 30
|
| Calico | Visit Calico for the first time. | 15
|
| Chest Nuts | Pick up all cash on all missions. | 15
|
| Chewing Volts | Use fifteen Energy charges. | 15
|
| Drop of Blood | Defeat William Rentier. | 30
|
| E-Rodeo | Kill twenty enemies using the E-Combo. | 15
|
| Expert | Beat the game on Hard difficulty or higher. | 85
|
| Father's Day | Defeat William Rentier in less than six minutes. | 70
|
| Field Agent | Find all hidden perks. | 15
|
| In the Feels | Hit 45 weakspots. | 15
|
| Mighty Mitten | Kill ten enemies in a row using only Gauntlet after obtaining the Revolver. | 15
|
| Minor Deity | Defeat The Parasiter on Evil difficulty. | 30
|
| Monsterball | Cannonball enemies fifty times. | 15
|
| Novice | Beat the game on Novice difficulty or higher. | 15
|
| Pew Pew Die | Kill at least thirty enemies with each electrically-augmented firearm. | 15
|
| Pointless Violence | Perform fifteen finishers. | 15
|
| Sever Forever | Tear off hundred limbs from enemies. | 15
|
| Slam Champion | Slam enemies hundred times. | 15
|
| Spark of Hope | Activate the Supercharged Mode for the first time. | 15
|
| Then You Died | Defeat William Rentier on Evil difficulty. | 30
|
| Ticks and Leeches | Defeat The Parasiter. | 30
|
| Weird West Superhero | Beat the game on Evil difficulty. | 100
|
| Weren't You Listening? | Defeat the Bruch on Evil difficulty. | 30
|