| Title | How to unlock | 
|---|
| Action Junkie | Complete 200 campaign chapters. | 
| Amateur | Complete all 20 campaign chapters on Amateur. | 
| Amazon | Complete 15 campaign chapters with female characters. | 
| Any Port in a Storm | Use chrysalids for cover for 20 minutes. | 
| Badass | Attack 100 times with zero stamina. | 
| Big Baby | Crawl for 300 meters. | 
| Bone Breaker | Kill 100 enemies while sliding. | 
| By Any Means | Use an enemy’s weapon 100 times. | 
| Chuter Shooter | Kill 100 parachuting enemies. | 
| Combat Master | Perform a unique physical attack 300 times. | 
| Counter Attacker | Perform 300 counterattacks. | 
| Curious Fan | Finished playing Resident Evil 5 campaign. | 
| Dead Ringer | Be killed 200 times. | 
| Death Wish | Require saving 100 times. | 
| Decorated Agent | Earn all 175 different medals in the campaign. | 
| Earning Them Medals | Earn 2,000 medals. | 
| Easy Target | Require help 300 times. | 
| Enemy Expert | Get 300 kills. | 
| Enjoying the Scenery | Walk 5,000 meters. | 
| Executioner | Perform 300 coups de grâce. | 
| Face Smasher | Destroy 1,000 J’avo masks. | 
| Figure Collector | Collect all 78 figures. | 
| File Collector | Read all 80 files. | 
| Fire Hazard | Set 1,000 zombies on fire. | 
| Getting Good Grades | Complete all 20 chapters in the campaign with an S rank. | 
| Global Player | Play with 300 other players online. | 
| Going Out in Style | Be killed awesomely 50 times. | 
| Got Some Experience | Complete all 20 campaign chapters on Normal. | 
| Gunslinger | Hit enemies with a quick shot 1,000 times. | 
| Hardcore Player | Play Resident Evil 6 for 100 hours. | 
| Headshot Master | Make a headshot 1,000 times. | 
| Herb Sharer | Feed your partner 200 health tablets during the campaign. | 
| Hero | Rescue another player 300 times. | 
| I Got Hand | Kill 100 enemies with Piers‘ mutated arm. | 
| I Know What I'm Doing | Complete all 20 campaign chapters on Veteran. | 
| J'avo Juice | Play as a J'avo 300 times. | 
| Joyrider | Travel 500 kilometers with a vehicle. | 
| Kickin' Ass & Takin' Names | Defeat 10,000 enemies. | 
| Last Hurrah | Defeat 100 enemies while dying. | 
| Left My Mark | Tag 300 enemies with a marker. | 
| Lifesaver | Save other players from dying 100 times. | 
| Like a Duck to Water | Swim 1,000 meters. | 
| Lone Wolf | Complete all 20 campaign chapters by yourself. | 
| Mad Dasher | Dash for 5,000 meters. | 
| Manipulator | Use an enemy's attack to kill 300 other enemies. | 
| Medal Agent | Earn 1,500 medals in the campaign. | 
| Metal Muncher | Destroy 300 helicopters or tanks. | 
| My Skills | Earn a total of 200,000 skill points. | 
| Need a Pick-Me-Up | Consume 2,000 health tablets. | 
| Need My Meds | Use the first aid spray 100 times. | 
| Not an Acrobat | Use the zip-line 300 times. | 
| Open Season | Kill 300 animals. | 
| Party Time! | Play with 3 other players X times during a story intersection. | 
| People Eater | Play as a zombie 300 times. | 
| Phoenix | Recover on your own from dying 100 times. | 
| Potent Pugilist | Land a physical attack 1,000 times. | 
| Professional | Complete all 20 campaign chapters on Professional. | 
| Props to You | Praise your partner 100 times during the campaign. | 
| Relentless Attacker | Perform 300 successful follow-up attacks. | 
| Reloader | Reload 5,000 times. | 
| Rescue Me | Receive help 300 times. | 
| Resident Evil | Default title. | 
| Respect the Skills | Complete all 20 campaign chapters without seeing the game over screen. | 
| Resuscitated Agent | Saved from dying 100 times. | 
| Rock-Hard Buns | Traverse 500 meters on your backside. | 
| Rollin‘ with the Homies | Play online with a friend X times. | 
| Running My Shoes Off | Run 100,000 meters. | 
| Skill Collector | Purchase 80 skills. | 
| Slide 'n' Smash | Destroy 300 objects while sliding. | 
| Slip Slider | Slide 500 times. | 
| Stealth Killer | Perform 300 stealth kills. | 
| Tag Master | 300 enemies you tagged are killed by other players. | 
| The Chemist | Combine herbs 1,000 times. | 
| Title Collector | Earn 200 titles. | 
| Undercover | Use cover for a total of 100 minutes. | 
| Weapon Expert | Get 1,000 kills. | 
| Achievement | How to unlock | 
|---|
| A Revolting Development (15 points) | Complete Chapter 2 in Jake's campaign. | 
| Ada's Demise (15 points) | Complete Chapter 4 in Ada's campaign. | 
| After Her! (15 points) | Complete Chapter 3 in Chris' campaign. | 
| B.O.W.s Are Ugly (30 points) | Defeat 100 enemies that have come out of a chrysalid. | 
| Back in My Day (30 points) | Complete the entire game on Veteran. | 
| Big Trouble in China (15 points) | Complete Chapter 4 in Leon's campaign. | 
| Bob and Weave (15 points) | Counter an enemy's attack three times in row. | 
| Bring the Heat (15 points) | Take down an enemy from 50 meters away with a headshot using the thermal scope. | 
| Buried Secrets (15 points) | Complete Chapter 2 in Leon's campaign. | 
| Check Out My Dogs (15 points) | Customize your dog tags. | 
| Civilian Casualties (30 points) | Defeat the BSAA 100 times. | 
| Counterintelligence (15 points) | Complete Chapter 2 in Ada's campaign. | 
| Covered in Brass (30 points) | Earn 150 different medals. | 
| Down, Not Out (15 points) | Defeat an enemy while dying, then recover without any help. | 
| Duty Calls (15 points) | Complete Chapter 5 in Chris' campaign. | 
| Easy Pickings (30 points) | Eliminate all players as Ustanak in less than a minute. | 
| Everybody Dies (45 points) | Defeat 100 player-controlled agents and 100 player-controlled creatures. | 
| Finish What You Start (15 points) | Perform a coup de grâce on ten enemies. | 
| Flying Ace (15 points) | Pilot the VTOL without getting a scratch on it. | 
| Get on the Plane (15 points) | Complete Chapter 3 in Leon's campaign. | 
| Give a Little Push (15 points) | Knock ten enemies off a high place. | 
| Gone to Hell (15 points) | Complete Chapter 1 in Leon's campaign. | 
| Green around the Ears (15 points) | Complete the entire game on Amateur. | 
| Hard Choice (15 points) | Shoot the helicopter pilot with a Magnum at point-blank range. | 
| Heirlooms (30 points) | Collect all the serpent emblems. | 
| Held Captive (10 points) | Defeat Ustanak with only one Agent remaining. | 
| High Voltage (15 points) | Defeat ten enemies with a stun rod charge attack. | 
| I Prefer Them Alive (15 points) | Rescue two female survivors at the cathedral. | 
| I Spy (15 points) | Complete Chapter 1 in Ada's campaign. | 
| Invincible (30 points) | Defeat Ustanak without anyone on your team being captured. | 
| J'avo Genocide (15 points) | Defeat 500 J'avo. | 
| Kill or Be Killed (10 points) | Win while in the dying state. | 
| Killer Combo (30 points) | Achieve a 30-combo chain. | 
| Kung Fu Fighting (30 points) | Survive to the end only using physical attacks. | 
| Last Man Standing--Again (45 points) | Win five times in a row. | 
| Leave It to the Pro (90 points) | Complete the entire game on Professional. | 
| Let's Blow This Joint (15 points) | Complete Chapter 3 in Jake's campaign. | 
| Lifesaver (15 points) | Help or rescue your partner ten times. | 
| Mad Skillz (90 points) | Max out all the skills that allow you to level up. | 
| Money Talks (15 points) | Complete Chapter 1 in Jake's campaign. | 
| Murder Spree (30 points) | Defeat the BSAA as a creature without dying once. | 
| Normal Is Good (30 points) | Complete the entire game on Normal. | 
| Not without a Fight (45 points) | Defeat Ustanak 20 times. | 
| One Is Better Than None (15 points) | Purchase one skill. | 
| One Is Never Enough (10 points) | As Ustanak, capture a total of 50 humans. | 
| Protect and Serve (10 points) | Protect the BSAA without any of them getting hurt. | 
| Rescue the Hostages (15 points) | Complete Chapter 1 in Chris' campaign. | 
| Rising Up (30 points) | Earn a level-four title. | 
| See You Around (15 points) | Complete Chapter 5 in Jake's campaign. | 
| Silent Killer (15 points) | Use a stealth attack to take down five enemies. | 
| Sneaking Around (15 points) | Get through the aircraft carrier's bridge area without being noticed. | 
| Staying Alive (10 points) | Return to the game as a human character. | 
| Still on the Run (15 points) | Complete Chapter 4 in Jake's campaign. | 
| Stuntman (15 points) | Defeat 20 enemies with the Hydra using a quick shot. | 
| Surrounded on All Sides (45 points) | Send 2,000 enemies to your opponent's map. | 
| Take 'Em All Down (30 points) | Defeat 100 agents. | 
| Take the Stage (30 points) | Defeat your opponent and achieve victory in 3 stages. | 
| Team Effort (10 points) | Win without any members of your team being killed. | 
| The Longest Night (10 points) | Complete the tutorial. | 
| The Trouble with Women (15 points) | Complete Chapter 5 in Leon's campaign. | 
| There's Always Hope (15 points) | Complete Chapter 4 in Chris' campaign. | 
| They're ACTION Figures! (15 points) | Collect 3 figures. | 
| This Takes Me Back (15 points) | Complete Chapter 3 in Ada's campaign. | 
| Titular Achievement (15 points) | Earn 10 different titles. | 
| Tragedy in Europe (15 points) | Complete Chapter 2 in Chris' campaign. | 
| Two Sides of the Same Coin (10 points) | Win 10 times. | 
| Weapons Master (30 points) | Use all the weapons in the game and kill ten enemies with each of them. | 
| What's Next? (15 points) | Complete Chapter 5 in Ada's campaign. | 
| You Are S.O.L. (10 points) | Defeat your opponent 10 times with enemies you sent. | 
| Zombie Massacre (15 points) | Defeat 500 zombies. |