Successfully complete the main missions to unlock more Arkvoodle Cult missions.
Alien Artifact Detector
Successfully complete the final Arkvoodle Cult mission in Albion to unlock the Alien Artifact Detector.
B-Movies
Successfully complete the indicated task to unlock the corresponding movie under the "Archives" menu:
Closing: Successfully complete the game.
Closing Animatic: Collect 50 Alien Artifacts and successfully complete the game.
Destroy All Humans Wrap Party: Collect 10 Alien Artifacts.
Intro Movie Happy Mix: Collect 30 Alien Artifacts.
Opening Movie Animatic: Collect 20 Alien Artifacts.
Salad Days With Pox And Crypto: Collect 40 Alien Artifacts.
Burrow Beast (super weapon)
Successfully complete all Arkvoodle Cult missions to unlock the Burrow Beast.
Causing mass pain
Abduct a person with the Abducto Beam. Just after you select store, release L. They will slam into the saucer causing a huge bang.
Defeating Coyote Bongwater
When the battle begins, you should only have two weapons, the Zap-O-Matic and Disclocater. Neither of these weapons will work effectively enough to kill both Bongwater and the KGB agents. However at the start of the level, towards the left far wall, there is a large container of Revelade. Around these containers are small barrels. These are explosive barrels. Once the battle begins, quickly use the Jetpack to go towards the left side of the room. Once there, try to take cover behind one of the Revelade containers. While hidden, use your PK ability on one of the explosive barrels. Once you have it levitating, either quickly swing it at the KGB agent's or Bongwater's feet, or press Y again to push it towards them. Either will work, as the explosion is enough to take out almost all the KGB agents. Only about two to three explosive barrels are required to take out Bongwater. Do not get too close to the barrel when it explodes, as it will drain your shields drastically or kill you.
Defeating Mutants
Take out your Anal Probe and shoot it at the Mutant. The Mutant will turn back to a human. You do not have to kill the human. Just kill the purple mist that comes out of it. Do not let the purple mist touch anyone else. To kill the purple mist, you can use anything except the Anal Probe. The Disintergrator works the best.
Defeating the KGB Boss in Alibon
Avoid his first attack by staying in motion and hiding behind a pillar or a box. When he is finished, take out your Anal Probe an shoot him once. He should start to turn back to normal. If not, try again. When he is back to normal, zap the green gas in the air and finish him off with your Disintergrater Ray.
Defeating the Tanks
When you finish destroying the blimps, a lot of tanks will appear. If you are in Two Player mode, the player in the turret can shoot the tanks and the player that is flying can abduct hippies and drain power from the tanks.
Eddie's Sex Change Odd Job Easy Pass
First off you have to be a hippie chick to talk to Eddie. After talking to him scan his mind and the snatch his body. Go to the phone booth across the street and make the phone call. I had a hard time finding the lady while maintaining the Eddie disguise. If your disguise time is about to run out then press YELLOW to get out of the body, then take over his body again. This way Eddie won't die. The lady you have to target is in North Parliament. If you look at your map it is dead North of where it says Parliament, north of the landing zone 4.
Final Bay City Arkvoodle Cult mission
Start the final Arkvoodle Cult mission in Albion, then go back to Bay City.
Final Takashima Arkvoodle Cult mission
Collect 30 Alien Artifacts to unlock the final Takashima Arkvoodle Cult mission.
Flying
Play in Two Player mode. Have two players get on dumpsters next to each other. Use PK on each other's dumpster and press Up. You can have the ultimate flying or on-foot flying.
Furotech Cell Detector
Successfully complete all Arkvoodle Cult missions to unlock the Furotech Cell Detector.
Gallery in Archives
Abduct the specified type of humans and then gene blend them. This allows you to view the Gallery in the Archives, but you still need to unlock the various types of stuff in the Gallery.
Hidden movie
Pause the game and select the "Movie" option. Then, click and hold the Left Analog-stick and press A, X, Y, B, X, B, Y, A(2) to see a movie featuring Crypto and Pox talking about the events from the original Destroy All Humans!
Quantum Deconstructor
The Datacore for the Quantum Deconstructor can be found by searching around the village of Tarkovskoye (in Tunguska). Pox will message you about the Datacore when you are close to it.
Screensaver
Remain idle and the screen will turn black and white, like an old television show.
Swingin' Jukebox
Successfully complete the indicated mission to unlock the corresponding music for the Swingin' Jukebox:
Albion Disguised: Mission 10
Albion Hunted: Mission 10
Albion Undisguised: Mission 10
Back In That Room: Mission 4
Bay City Disguised: Mission 5
Bay City Hunted: Mission 5
Bay City Undisguised: Mission 5
Destroy All Humans 2 Theme: Mission 19
Dirty Red: Mission 21
Down In The Valley: Mission 9
Help You Ann: Mission 12
Long Road: Mission 9
Moon Base Solaris Disguised: Mission 28
Moon Base Solaris Hunted: Mission 28
Moon Base Solaris Undisguised: Mission 28
Pattern Skies: Rage Of Aquarius side-mission
Pier 13: Mission 18
She Changes Like The Weather: Mission 3
Takoshima Disguised: Mission 16
Takoshima Hunted: Mission 16
Takoshima Undisguised: Mission 16
Tunguska Disguised: Mission 22
Tunguska Hunted: Mission 22
Tunguska Undisguised: Mission 22
Turn It Off: Mission 18
When You Touch Me: Rage Of Aquarius side-mission