| Trophy | How to unlock
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|---|
| Artery Medal (Bronze) | Gather 60 Golden medals in Veins Campaign mode.
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| Brain Folds Master (Silver) | Score 5000 kills in Brain Wars Immune Badass Survival mode.
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| Digest Warlord (Silver) | Complete all the Intestine Assault missions on Immune Badass difficulty.
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| Gold Farmer (Bronze) | Gather 60 Golden medals in Brain Wars mode.
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| Immune God (Silver) | Complete all Veins Campaign missions on Immune Badass difficulty.
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| Intestine Hard Day (Silver) | Score 5000 kills in Intestine Assault Immune Badass Survival mode.
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| Large Intestine (Bronze) | Gather 60 Golden medals in Intestine Assault mode.
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| Meticulous (Bronze) | Read all Help Guides and the Credits section.
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| Neurotic Lord (Gold) | Complete all the Brain Wars missions on Immune Badass difficulty.
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| No Help Needed (Bronze) | Destroy 500 powerups of any kind.
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| Pulse Master (Bronze) | Score 5000 kills in Veins Campaign Immune Badass Survival mode.
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