| Trophy | How to unlock
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| Beam Me Up, Germy! (Bronze) | Use a Warp Gate 5 times in a single Puzzle level.
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| Blinky, Pinky, Inky, and Sue (Silver) | Absorb a Red, Pink, Yellow, and Orange germ with a Blue Power Germ.
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| Breaking The Ice (Bronze) | Break the ice off of at least 10 germs in one level with 10 unique shots.
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| Campaign Queen (Silver) | Complete all 75 Levels of Campaign Mode, getting at least one star on each level.
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| Completionist (Gold) | Get all 450 stars in Campaign and Puzzle mode.
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| Cross Fire (Bronze) | Activate both a Yellow and Orange Power Germ in a single shot.
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| Germ-A-Go-Round (Bronze) | In a single shot, bounce a germ off of Deflectors and walls at least 12 times.
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| Highly Contagious (Bronze) | Get 20 or more Contagious Gummies on-screen at once in Arcade Mode.
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| Into The Spike Again, Dear Germs (Bronze) | In one level, have 10 germs you didn't shoot pop on Spikes.
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| Ms. Cupid (Bronze) | Activate a Pink Power Germ 12 times.
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| Puzzle Queen (Silver) | Complete All 75 levels of Puzzle Mode, getting at least one star on each level.
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| Star Struck (Bronze) | Collect all 3 Star Germs in 5 consecutive Campaign levels during one play session.
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| We Eat Contagions For Breakfast (Bronze) | Have a Blue Power Germ consume at least 3 Contagious Gummies when activated.
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