| Trophy | How to unlock
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| "RESPECT THE GAME!" (Bronze) | In any game mode, enter a game with a mismatching uniform.
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| A Year in the Life (Silver) | Play through one season (5 games) in Diamond Dynasty mode.
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| Back, Back, Back, Back, Back... (Bronze) | Hit a home run of 490ft or more in Home Run Derby.
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| Boom Goes the Dynamite (Bronze) | In any game mode, hit a home run with your first batter of the game.
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| Collector (Gold) | In Diamond Dynasty mode, acquire one of every card type. (Bronze, Silver, Gold, Platinum, MLB)
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| Congratulations! (Platinum) | You got all of the MLB 12 The Show Trophies!
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| Contact Killer (Silver) | In any mode excluding RttS, play an entire 9 inning game without striking out. Must be done in a full, uninterrupted, 9 inning game against a CPU controlled team.
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| Cruzball (Bronze) | Playing as the pitcher in any game mode, intentionally walk a batter, then turn a double play. Must be done against a CPU controlled team.
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| Deep Dish (Bronze) | Hit a home run into the Bullpen Sports Grill in rightfield at U.S. Cellular Field. (CWS)
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| Don't Phase Me Bro (Silver) | In any game mode, hit a home run off a 100+ MPH pitch. Must be done against a CPU controlled team.
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| Don't Try That Again (Bronze) | On defense, throw a runner out at 3B or home plate from the outfield. Must be done against a CPU controlled team.
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| Early Exit (Silver) | In any game mode, knock out the opponent's starting pitcher before the end of the 3rd inning. Must be done against a CPU controlled team.
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| Everyone's a Winner (Gold) | Win a game with every MLB team. Must be done in full, uninterrupted, 9-inning games.
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| Fish off a Barrel (Bronze) | Hit the aquarium behind home plate at Marlins Park. (MIA)
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| Free Baseball (Bronze) | In any game mode, win a game in extra innings.
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| Go Chasin' Waterfalls (Bronze) | Hit a home run into a waterfall at Kauffman Stadium. (KC)
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| In The Bag! (Bronze) | As the batter, hit 1st, 2nd, or 3rd base with the ball. Trophy is not achievable in Home Run Derby or Challenge of the Week.
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| King Slayer (Gold) | In Exhibition Mode, beat the team that is ranked first overall in the team select screen with Pitching and Batting difficulties set to Legend. Must be done in a full, uninterrupted, 9 inning game.
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| Loud and Clear (Bronze) | Hit a home run into the speaker in center field at Dodger Stadium. (LAD)
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| Masterpiece (Bronze) | Create a Diamond Dynasty team and custom logo including at least 20 layers.
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| Meatball Buffet (Silver) | Bat around in an inning. Must be completed on All-Star or higher Batting difficulty. Must be done in a full, uninterrupted, 9 inning game against a CPU controlled team.
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| Million Dollar Arm (Gold) | In any game mode, throw a perfect game against a CPU contolled team. Must be done in a full, uninterrupted, 9 inning game.
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| Plowman (Bronze) | As a baserunner, plow the catcher. Must be done against a CPU controlled team.
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| Pulsating (Bronze) | With the pitching difficulty set to All-Star or higher, use Pulse Pitching to strike out the side. Must be done against a CPU controlled team.
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| Quality Start (Silver) | Throw more than 70% first pitch strikes in a complete game victory. Must be done in a full, uninterrupted, 9 inning game against a CPU controlled team.
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| Run Benjie, Run! (Bronze) | Steal a base with a player whose primary position is Catcher. Must be done against a CPU controlled team.
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| Slinging in the Rain (Silver) | Play a full game in the rain without making an error.
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| Sombrero Dealer (Bronze) | In any mode, strike out the same player four times in a game. Must be done against a CPU controlled team.
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| Squeezeball (Silver) | In any game mode, win the game with an RBI bunt. Must be done in a full, uninterrupted, 9 inning game against a CPU controlled team.
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| Texas Two-Step (Bronze) | Hit a home run onto Greene's Hill in CF at Rangers Ballpark In Arlington. (TEX)
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| The Old Fashioned Way (Bronze) | In any mode, earn a save by having your reliever pitch the last 3 innings of a win. Must be done in a full, uninterrupted, 9 inning game against a CPU controlled team.
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| Vulture a Win (Bronze) | In any mode, blow a save and get the win with the same pitcher. Must be done in a full, uninterrupted, 9 inning game against a CPU controlled team.
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| Winning (Gold) | Hit 10 consecutive home runs in Home Run Derby.
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| You Blew It (Bronze) | In any mode, blow your opponents save opportunity. Must be done against a CPU controlled team.
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| Zone Plus Analog Blast (Bronze) | With hitting difficulty set to All-Star or harder, hit a home run using Zone Plus Analog controls. This trophy is not unlockable in Home Run Derby modes.
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