| Trophy | How to unlock
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|---|
| All Gummed Up (Bronze) | Lose any Story Mode level within 5 seconds.
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| Clean-a-rama (Bronze) | Get a combo-pop of 100 or more germs with one shot.
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| Feverish Cleaning (Bronze) | Complete a Story Mode level in under 30 seconds.
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| Germ-a-thon (Silver) | Complete 20 different levels in a single run in Puzzle Mode.
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| Micro-Cleaner (Silver) | Complete all Story Mode levels.
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| Mother of all Pops (Bronze) | Pop a germ of size 25x or greater.
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| Oozie (Bronze) | Fire 50 germs in a single Story, Duel, or Arcade level.
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| Photo Finish (Silver) | Win the 15th round in a Duel match against "The Germinator".
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| Sound Logic (Silver) | Complete all Puzzle Mode levels.
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| The Germinator (Gold) | Collect all stars in Puzzle and Story Mode.
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| The Inoculator (Bronze) | Survive for 5 minutes or more in Arcade Mode.
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| The Marksman (Bronze) | Finish any Puzzle level with a single shot.
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