In the first mission, when you man the machine gun to defend the base you will hear someone screaming 'They're coming out of the walls! They're coming out of the goddamn walls!' This is a reference to the movie Aliens.
Beating The Tank
Head for any ramp and stay out of the tank's sight. Use the telekinetic glove to grab the respawning ammunition to pounce the tank with rockets. Cortez wins, the tank does not.
Co-Op teleportation
If one character under control moves too far ahead of the other one, the one who was left behind will 'teleport' a few feet ahead of the first character, often resulting in strange camera angles.
Defeating the Deer Haunter
In the Brotherhood house, you will be trapped in a large room with zombies. Take out the zombies with your pistol and baseball bat, but save all the shotgun shells that you can. When you defeat them all, the Deer Haunter crashes through the wall. The key to defeating it is to walk in circles around the beast in the middle of the room, continually shooting it in the torso with your shotgun while taking minimal damage. When it is defeated, the door to the next room will open.
Defeating the techno-organic tank creature
Before you enter the room with the beast (at the checkpoint), take out all of the enemies in the room, then on the ground floor. Pick up the health and armor at either ends of the room. Go upstairs and turn right. Follow the landing around to the end to pick up some very powerful plasma grenades. Then, go into the room at the top of the stairs to face the tank creature. This beast spawns exploding worms from its rear. Remain close to the pillars to avoid being incinerated by the spreading explosions. As for the beast, aim your explosives and guns at the weapons it is packing on his back. These include lasers, machine guns, rockets and others. At any opportunity you get, throw the five plasma grenades you have and try to get them to stick to the weapons that have not been destroyed yet. These do a lot of damage to the beast. Keep hugging the pillars for cover. After awhile, you will have most of his guns. Do not aim for the organic parts of the creature, as it takes no damage. When it is defeated, you will meet Jacob Crow again.
Free The Jungle Queen
The optional task of freeing Captain Ash's ass-istant is easier than you think. Head into the prison cell on the other side and make a line of vertical holes on the metal drum from top to bottom. This creates the largest pool of petrol possible. Ignite the mess by shooting the lantern hanging from the ceiling and the ensuing explosion will give you a eyeful of T and A.
Hidden tunes in Story Mode
Go to the organ in Scotland the Brave. Press X and it will play certain tunes. The Baseball MusicHorrorAnaconda and another one too. You can hear them over and over again if you wish to.
Mansion Of Madness Defeating the Boss
To defeat The Princess, side-step in one direction while aiming up and turning. The closer that Cortez is to the fountain, the greater the chance to avoid being swiped. When the Boss is about to die, step back and fire the last shots to avoid the final death blow.
Taking out the energy sphere
In the factory where the TimeSplitters are being incubated, the giant energy sphere powering their growth can be taken out on the top level by flicking both the switches on either side of the ball. This will lower its defense. Then, take the lift down to the floor below and throw a plasma grenade (found next to the lift) at it, causing it to explode.
Unlock Anya and The General Characters
Beat first Story Mission.
Unlock Arthur Aching
Complete "Mansion Of Madness" on the easy difficulty setting.
Unlock Berserker Splitter
Beat the Hooded Man on easy.
Unlock Big Hands
Get 250 pts. or more on "Cortez cant Jump".
Unlock Big Heads
Complete Outbreak Hotel with a Bronze or higher.
Unlock Booty Guard
Beat Zany Zeppelin with a bronze or higher.
Unlock Braces
Complete "Old Blaggers" with a bronze or higher.
Unlock Brains
Complete "Brain Drain" with a bronze or higher.
Unlock Candi Skyler
Complete "Screw Loose" with a bronze or higher.
Unlock Captain Ed Shivers
Complete the Arcade League level Pirate Gold with a bronze or higher.
Unlock Carrion Carcass
Beat the challenge Rare or Well Done with a bronze or higher.
Unlock Cascade
Complete "Zone Control" with a bronze or higher.
Unlock Cascade
Earn Bronze, Silver or Gold in Zone Control Arcade League.
Unlock Chinese Chef
Complete "Ninja Garden" with a bronze or higher.
Unlock Comrade Papadov
Beat "Lap It Up" in under 2:15.
Unlock Corpreal Hart
Beat Future Perfect on medium.
Unlock Deadwina
Beat the Arcade League match I like Dead People with a bronze or higher.
Unlock Deep Diver
Complete "Oh Shoal-O-Mio" with a bronze or higher.
Unlock Dozer
Complete "Lip Up Fatty" with a bronze or higher.
Unlock Dr. Peabody
Get all golds or higher in Amateur League.
Unlock Elite Henchman
Beat the challengeMelon Heist on Monkeying Around with a bronze or higher.
Unlock Elite Henchwoman
Beat Khallos Express on medium.
Unlock Gaston Boucher
Complete "Mansion Of Madness" on the normal difficulty setting.
Unlock Gilbert Gastric
Beat "Cat"s Pajamas" under 2:35.
Unlock Hans
Complete "Freak Unique" with a bronze or higher.
Unlock Hechman Cortez
Beat The Russian Connection on medium.
Unlock Human Gun Sounds
Earn Bronze, Silver or Gold in Cats Out Of The Bag challenge.
Unlock Jacob Crow
Beat Future Perfect on easy.
Unlock Jacque de la Morte
Beat Vamping in Venice with a gold or higher.
Unlock Jared Slim
Complete "The Dead, The Bad And The Silly" with a bronze or higher.
Unlock Jo Barf Creepy
Complete Story mode level Mansion of Madness on normal or higher.
Unlock Jungle Queen
Beat Scotland the Brave on easy.
Unlock Karma Crow
Complete story mode on hard.
Unlock Kitten Celeste
Complete "The Khallos Express" on the easy difficulty setting.
Unlock Koozer Mox
Complete "A Pox Of Mox" with a bronze or higher.
Unlock Leo Krupps
Get a bronze medal or higher in the Honorary League challenge Rumble in the Jungle.
Unlock Leonid
Beat Big Game Hunt with a silver or higher.
Unlock Mad Old Crow
Beat Future Perfect on easy.
Unlock Mischief the Clown
Beat the third challenge on Monkeying Around with a bronze or higher.
Unlock Monkey Gun
Beat the challenge Eletrco Chimp Discomatic with a bronze or higher.
Unlock Mr. Fleshcage
Complete all challenges with at least a bronze for each.
Unlock Mr. Socky
Complete "Sock It To Them" with a bronze or higher.
Unlock Mr. Underwood
Beat the challenge Glimpse of Stocking with a bronze or higher.
Unlock Neophyte Constance
Complete "Freak Unique" with a bronze or higher.
Unlock Neophyte Lucian
Complete "Zone Control" with a bronze or higher.
Unlock Oleg
Beat the Timesplitters Underground challenge with a bronze or higher.
Unlock Prison Officer
Complete "Screw Loose" with a bronze or higher.
Unlock Pulov Yuran
Beat the challenge Plainly Off His Rocker with a bronze or higher.
Unlock Robot Louis Stevenson
Complete Story mode Level You take the Highroad on easy or higher.
Unlock Rotating Heads
Beat Dehead the undead with bronze, silver, or gold.
Unlock Slow Motion Deaths
Finish Rockets 101 with a Bronze medal.
Unlock Small Heads
Complete "A Pox Of Mox" with a bronze or higher.
Unlock Snowman
Beat the Arcade League level with a Gold or higher.
Unlock Spinning Heads
Complete Challenge Dehead the Undead with a Bronze or higher.
Unlock Stumpy
Complete "Front Loaded" with a bronze or higher.
Unlock Swinging Tipper
Complete "The Russian Connection" on the normal difficulty setting.
Unlock The Master
Complete Divine Immolation with a Bronze or higher.
Unlock Time Assasian
Beat The Hooded Man on medium.
Unlock Tommy Jenkins
Complete "Astro Jocks" with a bronze or higher.
Unlock Victorian Crow
Beat Future Perfect on medium.
Unlock Viola
Receive bronze in "Hart Attack" challenge.
Unlock Warrant Officer Cain
Complete "Scotland The Brave" on the normal difficulty setting.
Unlock Zombie Monkey
Earn Bronze, Silver or Gold in Brain Drain Challenge.
What Lies Beneath: Defeating the Boss
Use the Ghost Gun and position yourself carefully. Find a rock that shields Cortez's legs while allowing him to fire back. The fire attack from the Boss must drop to the floor before moving forward. The rock will protect you from most of the fire damage. Use a melee attack to kill the bats and allow the Ghost Gun to damage the tank.