| Achievement | How to unlock
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| 2UP! | Get 2 extra lives at the same time.
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| Amok in the Ammunition Depot | Defeat the boss in the Ammunition Depot.
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| Annie's Outfits | Unlock all colors for Annie.
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| Battle in the Sky | Defeat the boss of the Flying Ship.
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| Battle on the Armored Train | Defeat the boss on the Armored Train.
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| Bonus Baron | Get a x5 bonus with either Clint or Annie.
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| Bullet's Bark | Unlock all colors for Bullet.
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| Canyonero | Beat the Desolation Canyon stage without dying.
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| Carnage in Carson City | Defeat the boss of Carson City.
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| Carson City Mayor | Beat the Carson City stage without dying.
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| Clint's Fashion Show | Unlock all colors for Clint.
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| Depot Desperado | Beat the Ammunition Depot stage without dying.
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| Doggie Drone | Move Bullet to the top of the screen using the drone.
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| Doris's Day | Unlock all colors for Doris.
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| Gold Mine Gamble | Defeat the boss in the Gold Mine.
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| Greenhorn | Beat Single Player on Easy without using any continues.
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| Gunslinger | Beat Single Player on Hard with all characters without using any continues.
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| Lurking Underground | Defeat the boss of the Underground.
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| Maximum Impact | Have Doris charge up 7 grenades.
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| Mining Master | Beat the Gold Mine stage without dying.
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| Pardner | Beat Single Player on Normal with all characters without using any continues.
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| Ranch Hand | Beat Single Player on Easy with all characters without using any continues.
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| Sharpshooter | Beat Single Player on Hard without using any continues.
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| Ship Captain | Beat the Flying Ship stage without dying.
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| Showdown in Desolation Canyon | Defeat the boss of Desolation Canyon.
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| Sidekick | Beat Single Player on Normal without using any continues.
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| Sweet Revenge | Defeat Kid.
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| Train Takedown | Beat the Armored Train stage without dying.
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| Underground King | Beat the Underground stage without dying.
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| Wild Guns Reloaded Master | Beat the Final Fight stage without dying.
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