| Achievement | How to unlock
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| A Great Need for a Shower | Escape from the sewers.
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| A Hero Emerges | Complete Leon's story.
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| A Heroine Emerges | Complete Claire's story.
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| A Small Carbon Footprint | Take 14000 steps or fewer in one playthrough.
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| A Vault-like Mind | Open a portable safe.
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| A Waist of Space | Expand inventory slots to max.
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| Bon Appétit | Shoot the grenade you fed to an enemy.
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| Broken Umbrella | Witness the true ending.
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| Complete Vermin Extermination | Destroy all Mr. Raccoons.
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| Customizer | Customize a weapon.
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| Don't Need No Stinkin' Gun | Defeat an enemy with a knife.
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| Eat This! | Counterattack with a sub-weapon.
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| First Break-In | Open a dial safe.
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| Frugalist | Complete the game without using a recovery item.
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| Gotcha! | Defeat Stage 2 G using the crane only once.
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| Grim Reaper | Complete "The 4th Survivor" extra mode.
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| Hack Complete | Complete Ada's segment.
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| Hardcore College Student | Complete Claire's story on "Hardcore" game mode.
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| Hardcore Rookie | Complete Leon's story on "Hardcore" game mode.
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| Hats Off! | Shoot Tyrant's hat off his head.
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| Hide and Seek | Complete Sherry's segment.
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| Hip to Add Squares | Increase your inventory slots.
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| In the Blink of an Eye | Defeat Super Tyrant with 5+ minutes left until detonation.
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| Keep Their Heads Ringin' | Paralyze a licker's sense of hearing.
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| Leon "S." Kennedy | Complete Leon's story on "Standard" or "Hardcore" with an S rank.
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| Like Skeet Shooting | Shoot a zombie dog or a licker out of the air.
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| Lore Explorer | Read all of the files.
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| Master of Unlocking | Open all of the safes and locks in the game.
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| Minimalist | Clear the game without opening the item box.
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| Never-Ending Rain | Escape the police station.
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| One Slick Super-spy | Use only the EMF Visualizer to complete Ada's gameplay segment.
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| Path to the Goddess | Solve the Goddess Statue puzzle.
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| Sizzling Scarlet Hero | Complete Claire's story on "Standard" or "Hardcore" with an S rank.
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| That'll Hold 'Em | Use Wooden Boards to board up a window.
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| The Basics of Survival | Combine two items together.
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| Treasure Hunter | Using the photo hints, find 2 hidden items.
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| Vermin Extermination | Destroy a Mr. Raccoon.
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| Welcome to the City of the Dead | Make it to the police station.
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| With Time to Spare | Defeat Stage 4 G with 4+ minutes left until detonation.
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| Young Escapee | Escape the bedroom within 60 seconds during Sherry's segment.
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| Zombie Roundup | Kill 3 enemies at once with a sub-weapon.
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