| Achievemen | How to unlock
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| An apple a day... | Beat the game without hiring medic operatives |
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| Anarchy | Beat the game without hiring diplomats |
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| Careless | Community Idea: Win all 3 scenarios without using the "Heal Operative" operation on hard difficulty. |
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| Doctor | Win all scenarios on at least normal difficulty |
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| Dynamic Duo | Community Idea: Win all 3 scenarios by hiring only 1 additional operative on at least medium difficulty. |
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| Globetrotter | Finish at least one game with each starting location |
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| Headstart | Community Idea: Win all 3 scenarios after not treating nor quarantining for the first 4 turns on hard difficulty. |
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| Heroes | Get one operative per class to max level in one game |
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| Intern | Win all scenarios on at least easy difficulty |
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| Jack of all trades | Finish at least one game with each starting leader specialty |
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| Not on my watch | Beat the game without an operative dying |
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| Order Restored | When the player quarantines a city for the first time |
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| Pacifist | Beat the game without hiring security operatives |
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| Putting the Band Back Together | Upon hiring a third Operative for the first time |
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| Right Time, right place | Successfully finish all operations you start in one game |
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| Savior | Win all scenarios on hard difficulty |
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| Speedrun | Beat the game in less than 20 turns |
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| Tech-Head | 8 Researched Techs |
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| The First of Many | First time an Operation succeeds |
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| The Wheels are Spinning | When the player researches the first Tech on the Tech Tree |
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| Trial and Error | Beat the game without hiring scientist operatives |
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| V for Virus | When the player researches the first Trait in the Lab
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