| Achievement | How to unlock
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| A Horde Of Monsters | Cure 50 monsters in total.
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| A Legion Of Monsters | Cure 10000 monsters in total.
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| A Throng Of Monsters | Cure 200 monsters in total.
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| All Fired Up | Beat 100 random levels.
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| Architect | Build 500 rooms in total.
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| Butterfly Effect | Cause 8 more monsters to enter your hospital than was predicted.
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| Close Call | Beat a random level with exactly one death from losing.
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| Doctor Octopus | Cure 8 monsters in a single turn.
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| Emergency Room | Beat a random level with a ward at maximum capacity and cure rate.
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| Fuzzy Isle | Discover Fuzzy Isle.
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| Getting Warmed Up | Beat 10 random levels.
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| Ghost Island | Discover Ghost Island.
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| Going Big | Build 100 rooms in total.
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| Graduation | Finish all 8 tutorial levels.
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| Haunted Forest | Discover the Haunted Forest.
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| Lava Land | Discover Lava Land.
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| Luxury Healthcare | Beat a random level without ever having more than 4 wards.
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| Monster's Dozen | Cure 12 monsters in a single turn.
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| Mutant Mountains | Discover the Mutant Mountains.
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| Off The Beaten Path | Beat all optional puzzle levels.
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| On Death's Door | Have 12 monsters near death outside your hospital at once and continue to beat the level.
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| Spotless Record | Beat a random level without any monsters dying.
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| Starting Small | Build 10 rooms in total.
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| Suspicious Circumstances | Beat a random level with exactly one death.
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| Swamp Town | Discover Swamp Town.
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| The Final Challenge | Beat the final level.
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| The Gang's All Here | See all 6 types of monsters.
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| The Impatient Patient | Have a monster skip past 8 waiting monsters and continue to beat the level.
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| Walk It Off | Beat a random level without placing any rooms other than wards.
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| Wasn't That What I Was Supposed To Do? | Unknown.
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| Zounds Of Monsters | Cure 1000 monsters in total.
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