| Achievement | How to unlock
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| "Hey Five-O!" | Unlock Alley Witch.
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| "I don't eat junk food!" | Unlock She Wolf.
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| Altered Beast | Complete Chainfield.
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| Barrel-ly Legal | Defeat ten enemies with any throwable object.
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| Choose Your Own Adventure | Complete all three alternative endings.
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| Circling the Prey | Complete Greenbridge Park.
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| Combo Mania | Perform an Ultimate Combo.
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| Concrete Jungle | Complete The Abandoned Buildings.
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| Corporate Ladder | Complete Feller Corp.
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| Gutter Ballet | Complete The Sewer Network.
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| Insert Coin | Complete the game in Arcade mode.
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| Land of the Dead | Fight the people without tombstones.
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| Lycanthrope | Complete seven different levels with She Wolf.
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| Mayhem Rock City | Complete Riverside.
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| One Boss at a Time | Complete the game in Boss Mayhem mode.
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| Orange is the New Black | Fight the people with orange jumpsuits.
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| Pandora's Box | Complete The Old Docks.
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| Perfect! | Complete a section without taking any damage.
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| Spectral Overload | Complete Codex Entertainment.
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| Speeding Bullets | Defeat ten enemies with any firearm.
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| Street Food | Obtain five yellow consumables.
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| Street Wizard | Complete seven different levels with Alley Witch.
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| Sugar Rush | Obtain five blue consumables.
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| The Living Weapon | Complete seven different levels with Trouble.
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| The Powerhouse | Complete seven different levels with Dolphin.
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| The Telekinetic | Complete seven different levels with Star.
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| The Warriors | Complete The Old Subway.
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| U Can't Touch This! | Block three catch attacks.
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| Up The Irons! | Defeat ten enemies with any melee weapon.
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| Who Watches the Watchmen? | Fight the people with uniforms.
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| World Without Magic | Complete the game without fighting any spellcaster.
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