| Achievement | How to unlock
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| Abnormal Autopsy | Unlock the artifact Abnormal Autopsy.
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| Bingus Bongus | Unlock Bingus Bongus.
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| Blob Roulette | Unlock the artifact Blob Roulette.
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| Blobbath | Unlock the artifact Blobbath.
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| Blobmoon | Unlock the artifact Blobmoon.
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| Circle Of Self Control | Unlock the artifact Circle Of Self Control.
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| Cracked Heart | Unlock the artifact Cracked Heart.
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| Cursed Capsule | Unlock the artifact Cursed Capsule.
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| Dizzy Wizzy | Unlock Dizzy Wizzy.
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| Double Trouble | Unlock the artifact Double Trouble.
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| Enraged Amam | Kill 10 Amams.
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| Enraged Gaia | Kill 10 Gaias.
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| Enraged Magmus | Kill 10 Magmus.
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| Enraged Mumsa | Kill 10 Mumsa.
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| Enraged Zigrid | Kill 10 Zigrids.
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| Full Spectrum | Unlock the artifact Full Spectrum.
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| Gilded Handle | Unlock the artifact Gilded Handle.
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| Golden Bacharach | Kill Bacharach 50 times.
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| Golden Blobby | Kill Blobby 50 times.
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| Golden Blob | Kill 100 000 Blobs.
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| Golden Elite Blob | Kill 50 000 Elite Blobs.
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| Golden Elite Giant | Kill 2 500 Elite Giants.
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| Golden Elite Runner | Kill 10 000 Elite Runners.
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| Golden Elite Spider | Kill 15 000 Elite Spiders.
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| Golden Exploder | Kill 15 000 Exploders.
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| Golden Giant | Kill 5 000 Giants.
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| Golden Runner | Kill 50 000 Runners.
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| Golden Tick | Kill 7 500 Ticks.
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| Golden Ulla | Kill Ulla 50 times.
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| Golder Spider | Kill 25 000 Spiders.
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| Goober | Play Goobies for the first time.
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| High Tide | Unlock the artifact High Tide.
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| Hoozey Woozey | Unlock Hoozey Woozey.
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| Mutaded Gene | Unlock the artifact Mutated Gene.
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| Pixel Perfect | Unlock the artifact Pixel Perfect.
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| Pulverization | Unlock the artifact Pulverization.
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| Sign Of Time | Unlock the artifact Sign Of Time.
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| Spinky Winky | Unlock Spinky Winky.
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| Symbol Of Pain | Unlock the artifact Symbol Of Pain.
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| Tinctured Glimpse | Unlock the artifact Tinctured Glimpse.
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| Wrath Of The Elder | Unlock the artifact Wrath Of The Elder.
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| Yocto | Unlock the artifact Yocto.
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| Zigrids Last Wich | Unlock the artifact Zigrids Last Wish.
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