| Achievement | How to unlock
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| 49 in 5 | Get from the studio lobby to the boardroom without dying in 5 minutes.
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| A Sinister smush | Complete 'Front Gates of EEEEEEEVIL!'.
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| ARRR-Rated | Beat 'Death, Baby' while wearing the pirate hat.
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| Be like Joe | Bank a 300-hit combo.
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| Beer goggles | Use all three switches, defeat the two phasers, and chase after Vertigo within 60 seconds.
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| Caribou's Shoe | Complete 'Genosha'.
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| Catch me if you can | Defeat Arclight while taking no damage from her slam attacks.
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| Cole'd Blooded | Combo an entire wave on any Gold-tier Challenge map.
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| Curious about Cable | Play WTF is Cable.
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| Diggin' in the crates | Find 11 treasure chests in the darkness of the Tombs.
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| Drunk on power | Upgrade all weapons to max.
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| Fish out of water | Get through Toxic River without falling into or touching the water and taking damage.
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| Game On! | Heh heh, good times.
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| Game Over! | Stealth Kill Sinister, in the Prison, with the Sword!
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| Gold rush | Complete five Gold Challenges.
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| HEEEEY YOOOOO GUYYYYYSSSS! | Take no damage on the waterslide.
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| I am Deadpool | Complete 'Front Gates of EEEEEEEVIL!' from start to finish using only swords and pistols.
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| I can open doors! | Complete the Breach in 10 seconds.
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| I'm expecting company | Make a thousand pancakes.
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| In the lobby comboin' your dudes | Score a combo higher than 40 before they lock the elevators.
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| It's a trap! | Score a combo of 75 or more while fighting up the stairs at the 'Front Gates of EEEEEEEVIL!'.
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| JR's Big Adventure | Complete 'The Road to Victory'.
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| Know DP? Know madness | Complete the game on Ultra-Violence! difficulty.
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| Lady Deadpool-like | Complete 'Landed in Prison'.
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| Let's try one more time! | Slap Wolverine a bunch of times.
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| Let's-a-Go! | Make it across the floating debris without falling.
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| Makin' a game! | Playing with Deadpool's junk.
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| No Chance in heaven | Complete 'Taking a Chance'.
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| No DP? No madness | Complete the game on Veteran difficulty.
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| Officially a Carny | Get a high score at the Carnival.
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| Only when he stops breathing | Set the Dialog Volume slider to zero.
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| Patience is not a virtue | Choose the patience option all the way through the line in the Carnival.
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| PC LOAD LEAD-ER | Shoot up the copier in the bridge offices.
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| Poulos-Vision | Complete 'Death, Baby'.
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| Pull the grenade, throw the pin | Kill a total of 15 enemies by holding cooked grenades.
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| Remarkably quiet | Kill 4 enemies in the Tower Plaza with stealth kills.
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| Shall I? I Shanti! | In 'Genosha' reach the Fan Girl using only Hammers and Plasma Rifles.
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| Shields up | Complete a Gold- or Silver-tier Challenge while countering at least 25 times.
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| Silent and deadly | Get a stealth kill with every melee weapon in Sinister's Lair without being detected.
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| So you've got some free time? | Complete 'Landed in Prison' without countering any attacks.
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| Social butterfly | Interact with all the ladies at the Shower Surprise Party room.
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| Spawn more Deadpool-lords | Collect all DP points and ammo in the bathroom.
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| Suck it, Wolverine! | Complete 'Front Gates of EEEEEEEVIL!' from start to finish without dying.
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| Taco Savior | Collect 100 tacos.
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| The first one's free! | Get off your well-toned bottom.
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| The house that bounces | Complete 'Job One'.
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| The second one is also free... | Be pretty.
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| This game is rigged! | Shoot everything from the Wheel of Insanity (Balloons and the Cow).
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| Unbalanced | Purchase all Player Upgrades.
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| You've been Cole-slaw-tered! | Die 10 times in a row through the floating stairs.
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