After you survive the attack in the house, make sure you still have the incendiary grenade from upstairs. When you see the Merchant, look at his eyes with a rifle. If they are red, throw the incendiary grenade at him. He will scream like one of the male villagers does when you throw an incendiary grenade at them. Note: In different areas the scream will be different. For example, at the island he will scream like a soldier.
Ada Wong
Get a four star rating or higher in the Pueblo map.
Albert Wesker
Get a four star rating or higher in the Waterworld map.
Alternate controls
Disconnect the Nunchuck when the game loads. When prompted to attach the Nunchuck, attach the Classic Controller instead. You can play classic style Laser Sight and all.
Remove the Nunchuck, and insert a GameCube controller into port one. You will now have a laser sight on your weapons and be able to use all of the GameCube's normal controls. Note: This is very helpful for sniping.
Alternate Title screen
Complete the main game once.
Ashley is indestructible
When Ashley is wearing her alternate armor suit she is indestructible. If anyone tries to pick her up they will fall down. When knives, bows, or chainsaws hit her, she is unaffected. When you play as Ashley and a zombie grabs you by the neck, he drops you immediately. When the movable armor suits swing their swords down on her she never gets hurt. When Leon has to catch Ashley he catches her and nearly falls over then holds his back in pain. When Ashley crawls on his back he grunts in pain.
Ashley's knight armor
Beat Separate Ways once.
Ashley's pink outfit
Beat the main game once.
Assignment Ada
Beat the main game once.
Avoiding enemies at start
After you use the chief's false eye to open the door, walk up the hill until the truck comes at you. Shoot it and get back. Once it explodes, walk back up the hill, but go backwards. Keep going all the way to the castle and you will avoid facing the enemies that would normally appear.
Use the following trick to get through the town the first time. Rather than wasting ammunition and possibly dying, after you enter the house, run upstairs, kick out the ladder, and jump out. Then, go to the top of the tower in the corner of the town. The villagers will throw Molotov cocktails into the tower, but they cannot kill you. After awhile the villagers will go into the church. After this happens you can use Herbs or a First Aid Spray to restore your health. Because the villagers are gone, you can also check the houses for ammunition and PTAS.
Chicago Typewriter
Pass Assignment Ada once.
Costume change
After completing Separate Ways, select Special Outfit #2. During some of the intermission sequences (for example, the scene after the village), Leon will be in his standard clothes. After the scene, he will then be in the special outfit.
Defeating Chief Mendez
When you enter the building where you fight Chief Mendez, or "The Big Cheese", there is a glitch that will allow you to defeat him with minimal damage. After the short intermission sequence where Leon blows up Chief Mendez with the gas tank, you will have to fight him. Run up the ladder directly behind to go to the catwalk then go left. Go left again on the catwalk. There will be a group of metal boards nailed to the railing atop the catwalk. If you wait there for about five seconds and remain absolutely still, Chief Mendez will just keep walking into the catwalk, and not be able to hurt you. If you are observant enough, you can see a small square cut out of the bottom right corner of the boards. You will be able to shoot him in the face, and he cannot hurt you. This may not work if you are standing too far to the left or right of the boards on the railing. This also only works when he is in his first centipede-like mutation. It only works before he begins swinging on the beams.
Defeating El Gigantes
When fighting an El Gigante in its second form, take out your Killer 7 and shoot the parasite, or climb on its back and cut it. Either way, this saves health, ammunition, and a lot of frustration. Note: This is really only beneficial if you do not have one of the special weapons.
Defeating Krauser
When fighting Krauser, it is easier to fight him using your knife than shooting him. If you shoot him, he will usually block and counter. To avoid this, slash him three or four times. He will then either kneel or flinch. When he does this, take out your strongest weapon and shoot him. If you are low on bullets, you can use grenades and mines. If you are playing Separate Ways, it is easier to use your knife the entire time.
Defeating Milita
Instead of shooting for their head, shoot them in the knee, then walk up to them. Instead "Kick", "Suplex" will appear. This will usually kill them instantly. This will not work if their head is armored.
Defeating the Chainsaw Ganados
Use the following trick to defeat the Chainsaw Ganados on the mine cart easily. Make sure you have a Rocket Launcher and the Broken Butterfly Magnum from the castle. Also, have over six magnum rounds. When the first Chainsaw Ganado appears, shoot the Rocket Launcher at him before the other Ganados get in the way. For the second one, pump all your Magnum rounds into him. If that does not kill him, then use your Striker or Riot Gun. Note: You might get damaged during all of this; make sure that you have at least three First Aid Sprays, and two Herb Mixes (Green, Red, or Green, Red, Yellow) to use if your health gets too low.
Defeating the Regenerator
If you find your rifle is empty, you can also defeat the Regenerator by shooting a mine into the spot around the parasite. If it is on its back, shoot out its legs with your handgun, then fire a mine into its back. If this does not work, find out where the parasite is on the Regenerator and try again.
When low on bullets, shoot the Regenerator in the leg with a powerful gun (for example, the magnum, rifle, or shotgun). It will fall to the ground. Run up to it and attack it with the knife. Once you start attacking it, it will not be able to fight back or stand up. Keep attacking it until it dies. Note: Regenerators can attack you while they are on the ground, so you may get hit once. However, this technique saves much needed ammunition for the island and sewers. Make sure to have at least an Herb and be ready for an action command.
Defeating U3 (It)
While you are in the giant crates, you can maneuver around U3. When you get to the gate, it will follow you. Run around and shoot it, bringing it closer to the explosive barrels. When you run out of barrels, fire either your shotgun or magnum.
Ditman Glitch
Go to the inventory screen and select the Stricker. Exit from the inventory and press the B button and then quickly press the minus button. Equip any weapon besides the Stricker and leave the inventory screen. Now the glitch is activated and you can move twice as fast and shoot twice as fast but once you select the Stricker, the glitch will be deactivated.
Easily unlock characters in Mercenaries mode
When starting Mercenaries mode, play as Leon and go to the castle. It is much easier to get a good ranking because you can give the enemies a suplex, which almost always kills them in one hit. When you get Jack Krauser from the castle, you can then go to other areas, and it will make it much easier because of his arm.
Easily Unlocking Hunk In Mercenaries
First, go to the third level. This is where you can unlock Hunk to play as in The Mercenaries. If you have other characters, ignore them. Pick Leon.
This level is very easy. Every enemy will die with only two hits. An important thing in this level is not to use the knife, because it does not have that much power and it will waste time.
First, run around shooting every enemy twice. Only use the knife to occasionally break open barrels for ammo and healing items. Once you see a clock, do not hesitate to pick it up, and do not leave it for when you need it. Pick it up immediately. Eventually, the large men wielding the turrets will show up. Avoid them mostly, and only kill them when you have the advantage. Also, when you kill them, make sure there are no other enemies close. If you ever get crowded, use the riot gun you are given. Also, use the riot gun on the men with the turrets. Only use healing when you need it. Use green herbs first, and when you run out, use the first aid sprays, but only when one more hit will kill you, or if you are unsure that you will survive another hit. Don't forget to keep picking up the clocks, and drop from ledges and run in different directions to evade the wild fire of the turrets.
By the end, as long as you score at least 40,000 points, you will get a four-star rating. 60,000 points will get you a five-star rating.
Easy money
When you get to the church, shoot the bell. Every three times you shoot it, some villagers will appear. Kill them, and you will get anything from Pesetas to ammo and herbs. You can do this as many times as desired. This is effective if you have a lot of ammunition or the Chicago Typewriter.
To earn easy money while playing through the game again, carry an empty Handcannon. It costs no money to have, but you will pick up ammunition for it occasionally. This is worth more than any other type of ammo in the game. After collecting the ammunition, sell it to the merchant. Try using the Chicago Typewriter as your main gun while doing this.
Easy way to kill Salazar
There is an area in the castle where there is a large glass case with ammo and weapons in it. A rocket launcher will be included. Take it, and save it for the Salazar boss battle.
Right before you enter the room where you have to fight Salazar, there will be a merchant. If you do not have a rifle yet, buy one. Then go in to face Salazar.
Salazar mutates into a giant monster that has a large yellow eye. Stand back so you don't get hit, and shoot the eye once with the rifle. It will severely hurt the monster, and a part of it will open up to reveal the head and upper body of Salazar. Go to your inventory, select the rocket launcher, and shoot Salazar. It will kill him immediately.
Extra Firepower
During the game, there are fifteen blue medallions you have to shoot, seven in the farm, eight in the graveyard and along the bridge to the lake. If you shoot at least ten of the blue medallions, the merchant will give you a new handgun, the Punisher. It will more firepower than the first handgun, but not a lot more. However, if you shoot all fifteen blue medallions, the Punisher will have an extra amount of firepower to it when you get it.
HandCannon
Get a 5 star in all stages with all characters in the Mercenaries.
Hidden videos
There are two hidden cinematics accessible at the title screen. One can be accessed by remaining idle at the main menu until it starts. The other can be seen by pressing B on the Wii-mote at the main menu.
HUNK
Get a four star rating or higher in the Island map.
Infinite Rocket Launcher
Pass the game once.
Jack Krauser
Get a four star rating or higher in the Castle map.
Keeping money
After you beat the main game once, you can select "Load" on the main screen and load the game you have already beaten. Do this, and you can buy more guns from the merchant if you choose to. If you do, you will spend some of the money you had when you beat the game. After starting the game, you will have everything you had when you accomplished the first game.
It is okay to save. If you choose to load the profile that you beat the game with and start a new game off of it, all of the money will still be there.
Leon hat trick
To make Leon do a special trick with his hat, unlock the gangster costume and Chicago Typewriter. At any point in the game while in Leon's gangster costume, take out the Chicago Typewriter, aim, and shake the Wii-mote to reload. Leon will make a noise and move his hat. If you do this four times, he will throw his hat in the air and catch it on his head.
Leon S. Kennedy
Initially available.
Leon's R.P.D. uniform
Beat the main game once.
Leon's suit
Beat Separate Ways once.
Luis kills Leon
During the house scene shortly after getting Ashley, shoot Luis five or six times. There will be an intermission where Luis is shot in the arm. He will then say "Adios, Leon!" and shoot him twice in the heart. Note: This will cause a game over.
Maltilda
Pass the game once.
Mercenaries
Beat the main game once.
Mercenaries mode: Alternate costumes
Highlight a character, then select them as indicated to unlock their alternate costume.
Assignment Ada costume: Hold [Plus] and press A.
Leon with jacket: Hold 1 and press A.
Leon with suit: Hold [Plus] + 1 and press A.
Leon's Raccoon City Police Department uniform: Hold [Plus] and press A.
Separate Ways costume: Hold 1 and press A.
Mercenaries mode: Easy unlocking characters
When starting Mercenaries mode, play as Leon and go to the castle. It is much easier to get a good ranking because you can give the enemies a suplex, which almost always kills them in one hit. When you get Krauser from the castle you can then go to other areas, and it will make it much easier because of his arm.
Mercenaries: Bonus characters
Get a four star or higher rank in the indicated Mercenaries mode level to unlock the corresponding character in Mercenaries mode.
Ada Wong: Pueblo
Albert Wesker: Waterworld
Hunk: Island
Jack Krauser: Castle
Missing platform
When you go into the room to fight Salzaar, look in front of Leon. The room looks just like when you fight him. However when you step forward, there is an intermission sequence where Salazaar is standing on a platform that was not there before with one of his guards.
Movie Browser
Beat the main game once.
Opening doors quicker
When the "Open" command appears by a door, tap A(2) to kick it open quickly. Doing this will also damage any enemies behind the door at the time you kick.
Plagas Removal Laser (PRL 412)
Beat the main game on Professional Mode.
Reticule feedback
Equip your handgun and aim the on-screen reticule at any torch or suspended light. Some times the reticule will turn red and deliver a slight jolt in the Wii-mote to indicate ammunition or a treasure that you can shoot from the light and retrieve. This is a slight advantage not available in previous versions of the game.
Saving ammunition
If you find yourself surrounded by some parasites of Los Ganados or los Illuminados and do not want to waste ammunition, quickly throw a flash grenade. Once it explodes, it should make the parasites explode, saving your other ammunition.
After completing Separate Ways you will unlock the armor suit for Ashley. Press Plus to make her wait and run a short distance away. If an enemy tries to pick her up in the suit they will fall down, as if they were shot in the leg. When this happens, run up and attack them with your knife until they get up. You can also use her to distract enemies and take them on one at a time.
When playing through the game under the Professional difficulty, you may find yourself running out of ammunition just before a part where you desperately need it. When this happens, run back to a merchant and upgrade your weapon's "Capacity". This will refill your clip with extra ammunition, giving you a full chamber.
Secret Area
When you are on Chapter 1-1, you will come across a farm area. It is where you first learn about the blue medallions. After you have finished with the area, go into the large farmhouse, ahead of where you find the note about the blue medallions. Go to the second floor, and then go out the window. You will then be on a walkway. Walk all the way down, and you will see a place with a ladder. Jump down, and go left. When you get to the edge of the fence, look to your left, and there will be a small hidden area with a few crates that have items in them.
Separate Ways
Beat the main game once.
Spinel
When enter the bedroom after the garden, look on the roof of the bed. You should see a sparkling object. It is a spinel.
Stupid enemies
Equip the shotgun and find a small area with a door. When at least two enemies come through, shoot the one that is closest to you. The other should run back through the door and go to a different part of the area you are in, as if you were somewhere else. Note: This will sometimes not work. Also, this can only be used for a short break in a fight; the enemy will somehow regain his or her senses and go back to you in after several seconds.
Wii Edition credits
Beat the main game once, then check the Bonus option in the Extras section of the main menu. You'll see an option for Wii Edition credits and can view the people responsible for porting Resident Evil 4 for the Wii.