Make a diversion by buffing up a creature that is not too important to you, as it will likely make your opponent target it, but choose a durable card.
Focus your attacks on opponent's strongest card as the battle will be far easier to win once you get rid of it.
The floop meter, the purple meter listed below your character's picture, will give you a floop card once it's filled. Use it when you find yourself in some sort of trouble.
Like in a lot of games signing into a game once per day will grant you a bonus loot, in this game in the form of a skeleton chest filled with random stuff.
Match the cake type with the creature type for bonus experience points. So, corn cake with corn creature.