| Achievement | How to unlock | Points
|
|---|
| 1000000% | Just Stop! | 50
|
| 1001% | Collect all items and unlock all secrets. | 50
|
| A Blank Card | Kill Isaac with Eden. | 15
|
| A Fetus in a Jar | Kill Mom's Heart nine times. | 15
|
| A Quarter | Kill Mom's Heart 8 times. | 15
|
| A Secret Exit | Complete ??? 3 times. | 15
|
| Apollyon | Kill Mega Satan. | 30
|
| Azazel | Make three deals with the devil in one run. | 15
|
| Basement Boy | Beat the Basement/Cellar without taking damage. | 20
|
| Bethany | Beat Hard mode as Lazarus without losing a life. | 15
|
| Blood Rights | Kill Satan with Samson. | 15
|
| Bloody Lust | Kill Isaac with Samson. | 15
|
| Blue Baby | Kill Mom's Heart ten times. | 15
|
| Boss Rush | Beat the Boss Rush. | 20
|
| Broken Ankh | Kill Satan with Lazarus. | 15
|
| Cain | Hold 55 or more pennies at one time. | 15
|
| Cambion Conception | Kill ??? with Lilith. | 15
|
| Challenges | Beat all twenty Challenges. | 20
|
| Daemon's Tail | Kill Satan with Azazel. | 15
|
| Dark Boy | Beat the Depths/Necropolis without taking damage. | 20
|
| Dark Room | Beat the Dark Room. | 15
|
| Dead Boy | Beat the Chest or Dark Room without taking damage. | 20
|
| Dead God | RIP | 60
|
| Death Certificate | ... | 30
|
| Deep Pockets | Kill ??? with Keeper. | 15
|
| Delirious | Beat Delirium. | 30
|
| Eden | Beat the Womb for the first time. | 15
|
| Eve's Bird Foot | Kill Isaac with Eve. | 15
|
| Everything Is Terrible | Kill Mom's Heart five times. | 15
|
| Eve | Beat two levels in a row without picking up any hearts. | 15
|
| Forget Me Now | Kill Satan with ???. | 15
|
| Golden God | You are the best! | 30
|
| Greedier! | Donate 500 coins to the Greed Machine. | 15
|
| Guardian Angel | Kill Satan with Maggy. | 15
|
| Isaac's Heart | Kill Isaac with The Lost. | 15
|
| Isaac's Tears | Kill Isaac with Isaac.test | 15
|
| It Lives | Kill Mom's Heart eleven times. | 15
|
| Jacob & Esau | You are just like your father... | 15
|
| Judas' Tongue | Kill Satan with Judas. | 15
|
| Judas | Kill Satan. | 15
|
| Karma | Kill The Lamb with Keeper. | 15
|
| Keeper | Donate thousand coins in Greed Mode. | 30
|
| Lazarus' Rags | Kill Isaac with Lazarus. | 15
|
| Lazarus | Have four or more soul hearts at one time. | 15
|
| Lilith | Beat Greed Mode with Azazel. | 15
|
| Little Baggy | Collect two of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball. | 15
|
| Lost Poster | Beat the Dark Room with Isaac. | 15
|
| Magdalene | Have seven or more max red hearts at one time. | 15
|
| Mama's Boy | Beat the Womb/Utero without taking damage. | 20
|
| Mega Mush | Beat everything in Hard Mode as every character. | 30
|
| Mom's Knife | Kill Satan with Isaac. | 15
|
| New Area | Unlocked a new area. | 15
|
| Platinum God | Collect all items and unlock all secrets and endings. | 40
|
| Real Platinum God | 100% the game! | 50
|
| Red Key | The other side is calling... | 15
|
| Samson | Beat two levels in a row without taking damage. | 15
|
| Something Cute | Beat the Caves thirty times. | 15
|
| Something Sticky | Beat the Depths twenty times. | 15
|
| Something from the Future | Beat the Basement fourty times. | 15
|
| Spelunker Boy | Beat the Caves/Catacombs without taking damage. | 20
|
| Succubus | Kill The Lamb with Lilith. | 15
|
| The Bomb Bag | Kill Satan with Cain. | 15
|
| The Book of Secrets | Kill Satan with Eden. | 15
|
| The Book of Sin | Kill all seven sins. | 15
|
| The Chest | Beat the Chest. | 15
|
| The Coin Bag | Kill Isaac with Cain. | 15
|
| The Forgotten | Uncover some lost remains... | 30
|
| The Gate is Open! | Kill The Lamb. | 15
|
| The Guillotine | Kill Isaac with Judas. | 15
|
| The Halo | Kill Mom using the Bible. | 15
|
| The Lost | Finish the game's final secret. | 20
|
| The Mind | Kill Satan with The Lost. | 15
|
| The Negative | Beat Sheol five times. | 20
|
| The Polaroid | Beat Cathedral five times. | 20
|
| The Razor | Kill Satan with Eve. | 15
|
| The Relic | Kill Isaac with Maggy. | 15
|
| The Satanic Bible | Kill Isaac with Azazel. | 15
|
| The Womb | Kill Mom. | 20
|
| Transcendence | Kill Mom's Heart 3 times. | 15
|