| Achievement | How to unlock
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| 49 in 5 (10 points) | Get from the studio lobby to the boardroom without dying in 5 minutes.
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| A Sinister smush (20 points) | Complete "Front Gates of EEEEEEEVIL!".
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| ARRR-Rated (10 points) | Beat "Death, Baby" while wearing the pirate hat.
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| Be like Joe (50 points) | Bank a 300-hit combo.
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| Beer goggles (20 points) | Use all three switches, defeat the two phasers, and chase after Vertigo within 60 seconds.
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| Caribou’s Shoe (20 points) | Complete "Genosha".
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| Catch me if you can (10 points) | Defeat Arclight while taking no damage from her slam attacks.
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| Cole'd Blooded (50 points) | Combo an entire wave on any Gold-tier Challenge map.
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| Curious about Cable (10 points) | Play WTF is Cable.
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| Diggin' in the crates (10 points) | Find 11 treasure chests in the darkness of the Tombs.
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| Drunk on power (50 points) | Upgrade all weapons to max.
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| Fish out of water (10 points) | Get through Toxic River without falling into or touching the water and taking damage.
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| HEEEEY YOOOOO GUYYYYYSSSS! (10 points) | Take no damage on the waterslide.
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| I am Deadpool (30 points) | Complete "Front Gates of EEEEEEEVIL!" from start to finish using only swords and pistols.
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| I can open doors! (10 points) | Complete the Breach in 10 seconds.
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| I'm expecting company (10 points) | Make a thousand pancakes.
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| In the lobby comboin' your dudes (10 points) | Score a combo higher than 40 before they lock the elevators.
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| It's a trap! (10 points) | Score a combo of 75 or more while fighting up the stairs at the "Front Gates of EEEEEEEVIL!".
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| JR’s Big Adventure (20 points) | Complete "The Road to Victory".
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| Know DP? Know madness (30 points) | Complete the game on Ultra-Violence! difficulty.
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| Lady Deadpool-like (20 points) | Complete "Landed in Prison".
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| Let's try one more time... (10 points) | Slap Wolverine a bunch of times.
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| Let's-a-Go! (10 points) | Make it across the floating debris without falling.
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| Makin’ a game! (20 points) | Play with Deadpool's junk.
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| No Chance in heaven (20 points) | Complete "Taking A Chance".
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| No DP? No madness (30 points) | Complete the game on Veteran difficulty.
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| Officially a Carny (10 points) | Get a high score at the Carnival.
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| PC LOAD LEAD-ER (10 points) | Shoot up the copier in the bridge offices.
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| Poulos-Vision (20 points) | Complete "Death, Baby".
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| Pull the grenade, throw the pin (50 points) | Kill a total of 15 enemies by holding cooked grenades.
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| Remarkably quiet (10 points) | Kill 4 enemies in the Tower Plaza with stealth kills.
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| Shall I? I Shanti! (50 points) | In "Genosha," reach the fan girl using only Hammers and Pulse Rifles.
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| Silent and deadly (20 points) | Get a stealth kill with every melee weapon in Sinister’s Lair without being detected.
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| So you've got some free time? (50 points) | Complete "Landed in Prison" without countering any attacks.
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| Social butterfly (10 points) | Interact with all the ladies at the Shower Surprise Party room.
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| Spawn more Deadpool-lords (10 points) | Collect all DP points and ammo in the bathroom.
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| Suck it, Wolverine! (10 points) | Complete "Front Gates of EEEEEEEVIL!" from start to finish without dying.
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| Taco Savior (10 points) | Collect 100 tacos.
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| The first one's free! (10 points) | Get off your well-toned bottom.
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| The house that bounces (20 points) | Complete "Job One".
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| The second one is also free... (20 points) | Be pretty.
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| This game is rigged! (10 points) | Shoot everything from the Wheel of Insanity (Balloons and the Cow).
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| Unbalanced (30 points) | Purchase all Player Upgrades.
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