| Achievement | How to unlock
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|---|
| Artful Dodger ( 5 points ) | Complete a "No Damage" challenge.
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| Eye Candy ( 15 points ) | Take over the prefrontal cortex.
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| Eye for an Eye ( 10 points ) | Kill the King of the spleen.
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| In a Nut Shell ( 15 points ) | Take over the duodenum.
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| Jack the Ripper ( 5 points ) | Rip out an eye.
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| Limbo ( 5 points ) | Complete a level without collecting any pickups at all.
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| Mr. Immortal ( 10 points ) | Complete all levels without dying.
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| Napoleon ( 20 points ) | Get 3 stars on all levels.
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| Perfection ( 5 points ) | Make a perfect run.
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| Pickup Truck ( 10 points ) | Collect all pickups in the game.
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| Play it Safe ( 10 points ) | Complete a level without taking any damage.
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| Shell Out ( 10 points ) | Kill Mama Amygdala.
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| Slay Away ( 10 points ) | Eat 5 eyes super fast!.
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| Slice N' Dice ( 15 points ) | Defeat Papa Cerebellum.
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| Soupe a'la Turtle ( 5 points ) | Kill a Turtlepoodle.
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| Speed Devil ( 5 points ) | Complete a time challenge.
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| Tentaculous ( 20 points ) | Complete the game.
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| The Small Escape ( 10 points ) | Escape Dr. Phluff's acid attack.
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| When I Say Jump ( 10 points ) | Complete all challenges.
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| Worm Eater ( 5 points ) | Defeat the Queen of the Colon.
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