| Effect | Code
|
|---|
| 30 minute limit | 30M1 N1TS
|
| All enemies have permanently feared | FEAR M1NT
|
| All floors have the basement room tile set | BASE MENT
|
| All items except troll bombs mimic Issac's movement | KEEP AWAY
|
| Asocial enemies | CLST RPH0
|
| Axis aligned controls | AX1S ALGN
|
| Big head mode | T0PH EAVY
|
| Black body | PTCH BLCK
|
| Bravery | BRAVERY
|
| CRT display | B00B T00B
|
| Camouflage EVERYTHING! | WH0A WHAT
|
| Camouflage enemies | CAM0 F0ES
|
| Camouflage player | CAM0 K1DD
|
| Camouflage stuff | CAM0 DR0P
|
| Can destroy rocks | NFB8 3WSG
|
| Cathode rays! | B00B T00B
|
| Champion enemies | CHAM P10N
|
| Character and tears turn black | PTCH BLCK
|
| Character leaves fecal trail | BRWN SNKE
|
| Character only visible as brown shadow | CAM0 K1DD
|
| Character takes double damage | HARD HARD
|
| Charmed enemies | C0CK FGHT
|
| Christmas | CHRS TMAS
|
| Concussive enemies that move randomly | C0NF ETT1
|
| Confused enemies | C0NF ETT1
|
| Cowardice | C0WR D1CE
|
| Damage on a timer | THEG H0ST
|
| Dog Mode | ALM1 GHTY
|
| Don't stop moving | D0NT ST0P
|
| Doors open immediately, tears are harmless; Boss's health act as timers | PAC1 F1SM or PAC1 F1ST
|
| Downtempo-- | LARG HET0
|
| Downtempo | ANDA NTE
|
| Dyslexia | DYSL EX1A
|
| Easier game | 1337 HAXR
|
| Eligible enemies become champions | CHAM P10N
|
| Enemies become feared randomly | FRAI DN0T
|
| Enemies fight each other | C0CK FGHT orCLST RPH0
|
| Enemies only visible as brown shadows | CAM0 F0ES
|
| Enemies respawn when character leaves room; new items do not drop | C0ME BACK
|
| Enemies respawn | C0ME BACK
|
| Escape the Labyrinth | THRE AD
|
| Extra Gore | BL00 00DY
|
| F2P version | FREE 2PAY
|
| Farty sounds | FART SNDS
|
| Forever Unknown | VNKN 0WN
|
| Full heart damage | HARD HARD
|
| Glowing tears | TEAR GL0W
|
| Grayscale | KAPP A
|
| Grey character | KAPP A
|
| Heal the Blind | BRA1 LLE
|
| Health tempo | HART BEAT
|
| Hopelessly Lost | L0ST
|
| Horrible Curse | CVRS ED
|
| I once was Lost | F0VN D
|
| Ice Physics | 1CES KATE
|
| Illuminate Darkness | N1TE L1TE
|
| Incurable Blindness | BL1ND
|
| Inescapable Labyrinth | LABY RNTH
|
| Infinite Basements | BASE MENT
|
| Invisible character except for surrounding light effect | 1MN0 B0DY
|
| Invisible enemies | BL1N DEYE
|
| Invisible enemies | BL1N DEYE
|
| Invisible player | 1MN0 B0DY
|
| Jumbled in-game text | DYSL EX1C
|
| Kids' co-op mode | K1DS M0DE
|
| Know the Unknown | N0W1 KN0W
|
| Large pools of blood when enemies die | BL00 00DY
|
| Load screen always displays "Are You Sure You Want Me To Die?" | 1TEN DSHE or SUPA SWAG
|
| Movement tempo | SL0W 4ME2
|
| Mystery cards | FACE D0WN
|
| Mystery pills | MED1 C1NE
|
| No HUD | KEEP TRAK
|
| Pacifism | PAC1 F1SM
|
| Permanent Darkness | DARK NESS
|
| Pickups time out | G0NE S00N
|
| Pill names and descriptions appear as ??? | MED1 C1NE
|
| Point of no return | N0RE TVRN
|
| Poopy Trail | BRWN SNKE
|
| Reversed controls | DRAW KCAB
|
| Reversed controls | DRAW KCAB
|
| Scaredy enemies | FEAR M1NT
|
| Skittish enemies | FRA1 DN0T
|
| Slow motion while character is idle; music speed altered with movement speed | SL0W 4ME2
|
| Sound effects replaced with farts | FART SNDS
|
| Start with 69 coins and have to purchase all items and pickups | FREE 2PAY or PAY2 PLAY
|
| Stay out of the Maze | PATH F1ND
|
| Take damage when idle | D0NT ST0P
|
| Tarot cards are face down when collected | FACE D0WN
|
| The Blank | THEB LANK
|
| The lower your health, the slower the music | HART BEAT
|
| Ticking starts every 45 seconds, after 5 seconds character takes half heart of damage | THEG H0ST
|
| Tiny head mode | T1NY D0ME
|
| Total curse Immunity | BLCK CNDL
|
| Tricky pickups | KEEP AWAY
|
| Twelve heart damage | BRTL B0NS
|
| Unending Maze | MAZE
|
| Uptempo++ | PRES T0
|
| Uptempo | ALLE GR0
|
| Item | How to unlock
|
|---|
| A Quarter | Defeat Mom's Heart for the eighth time.
|
| Ball of Bandages | Defeat Mom for the first time.
|
| Black Candle | Donate 150 Coins to the Donations Box.
|
| Blue Map | Donate 10 Coins to the Donations Box.
|
| Book of Revelations | Defeat a Harbinger for the first time.
|
| Cube of Meat | Defeat Mom for the first time.
|
| Dr. Fetus | Defeat Mom's Heart for the ninth time.
|
| Experimental Treatment | Defeat Mom's Heart for the seventh time.
|
| Head of Krampus | Defeat Krampus for the first time.
|
| Ipecac | Defeat Mom's Heart for the sixth time.
|
| Little C.H.A.D. | Defeat C.H.A.D. for the first time.
|
| Little Chubby | Complete The Caves (or equivalent level) for the first time.
|
| Little Gish | Defeat Gish for the first time.
|
| Mom's Knife | Defeat Satan as Isaac.
|
| Monstro's Tooth | Complete The Basement (or equivalent level) for the first time.
|
| Razor Blade | Defeat Satan as Eve.
|
| Red Candle | Donate 400 Coins to the Donations Box.
|
| Rubber Cement | Defeat Mom's Heart for the second time.
|
| The Book of Sin | Defeat each one of the Deadly Sin enemies.
|
| The Halo | Defeat either Mom or Mom's Heart by activating The Bible.
|
| There's Options | Donate 50 Coins to the Donations Box.
|
| Transcendence | Defeat Mom's Heart for the third time.
|
| Wire Coat Hanger | Defeat Mom's Heart for the fourth time.
|