| Trophy | How to unlock
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|---|
| Allergic to First Aid Spray (Silver) | Finish the game without using a First-Aid Spray.
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| Apprentice of Unlocking (Bronze) | Obtain all keys and use them all.
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| Burned Alive (Bronze) | Defeat an enemy by burning them.
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| Dead, Dead, Deadski (Bronze) | Defeat a zombie by stomping on them.
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| Fashion Plate (Bronze) | Change into a costume.
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| Fileophile (Bronze) | Read all files.
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| Find Time to Combine (Bronze) | Combine every type of herb with each other.
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| From Zero to Hero (Silver) | Finish the game on Hard difficulty.
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| Guns are Too Quick (Bronze) | Defeat an enemy with a knife.
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| Here I Come to Save the Day (Bronze) | Attack an enemy to save your partner who is grappling with that enemy.
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| I Could Shoot, You Know (Silver) | Obtain all weapons.
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| I'm a Medic, Not a Bodybuilder (Bronze) | Try to push something heavy with Rebecca.
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| Misdirected Hostility (Bronze) | Destroy a zombie's legs.
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| S is for S.T.A.R.S. (Silver) | Finish the game with rank S.
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| Save Your Prayers (Gold) | Finish the game without saving.
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| This is How You Recycle (Bronze) | Create a Molotov Cocktail.
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| This is Serious Business (Silver) | Finish the game without using a recovery item (including Green Chemicals).
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| Wanna Go for a Ride? (Platinum) | Earn all trophies.
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| Who's Got the Herb? (Silver) | Finish the game without combining herbs.
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| Zero In (Bronze) | Defeat an enemy with a critical-hit headshot.
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