| Accesory | How to unlock
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| Backwards Baseball Cap | Get 250 kills with the Shotgun (Burger Face III).
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| Baseball Cap | Get 75 kills with pipe bombs (Splatter King III).
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| Brain Sucker | Get 250 kills with the Enforcer (Laser Seeking Missiles III).
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| Canadian Flag Logo | Get 75 kills with the Garter Pistol (Tiny But Deadly III).
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| Cheese Hat | Get 250 kills with the Ripper (Swiss Cheese III).
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| Detonator Logo | Get 250 kills with the Rocket Launcher (Boom Goes The Weasel III).
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| Hoplite Helmet | Get 75 melee kills (Punchy McPuncher III).
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| I Shot Stupid Logo | Get 250 kills with the Railgun (Right In The Eye III).
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| Jester Hat | Get 75 kills with trip mines (Watch Your Step III).
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| Military Hat | Get 250 kills with the Pistol (Size Doesn't Matter III).
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| Retro Duke Logo | Get 250 kills with the Devestator (Meat Grinder III).
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| Ski Goggles | Execute a frozen player 75 times (Ice To See You III).
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| Tie-Dye Shirt | Get 250 kills with the AT laser (Medium Rare III).
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| Uncle Sam Hat | Stomp on 75 enemies (Pee Wee Vermin III).
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| Wolf Logo | Get 75 kills with Steroids (Roid Rage III).
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| WTF Logo | Get 75 kills with exploding barrels (Smile You Son Of A Bitch III).
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| Achievement | How to unlock
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|---|
| A Good Dam Fight | Defeat the Battlelord on the Hoover Dam.
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| Air-Duke | Win air hockey with a score of 7-0 in the strip club.
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| Annihilation | Kill 100 aliens.
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| Balls of Steel | Earn a 1,000,000 pinball score in SP.
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| Baron von Nukem | Shoot down 20 alien fighters.
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| Beating the One-Eyed Worm | Defeat the Energy Leech.
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| Big Guns, Big Ships | Blow up 5 enemy gunships or dropships.
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| Bucket Head | Find all 3 helmets in the SP campaign.
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| Call Waiting | Listen to all phone messages.
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| Come Get Some | Complete the SP campaign on Hard Difficulty.
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| Companion Barrel | Unlock the secret closet at the end of the Forkstop.
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| Damn, I'm Good | Complete the SP campaign on Insane Difficulty.
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| Dead Useful | Kill 10 aliens with environmental explosives.
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| Drawrings | Doodle something on the whiteboard in SP.
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| Duke Angry, Duke Smash! | Kill 15 aliens with melee attacks while on steroids.
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| Extermination | Kill 50 aliens.
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| Flagon of Chuckles | Drink a beer in SP.
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| Fork the Pork | Kill 6 aliens with the forklift.
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| Freeze Well! | Kill 15 frozen aliens.
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| Full Body Tourettes | Get knocked down 10 times.
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| Gunslinger | Carry the gold pistol through the whole SP campaign.
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| He's Got a Hologram! | Use a Holoduke in SP.
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| Hippy-Stomper | Foot stomp 12 aliens.
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| I Am All That Is Man | Discover all ego cap rewards.
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| I Need a Date | Look at every page of a calendar in SP.
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| I Need a Towel | Get hit by 10 Pregnator bombs.
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| Judge, Jury, Executioner | Execute 20 aliens.
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| Juiced | Take steroids in SP.
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| Let's Rock | Complete the SP campaign on Normal Difficulty.
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| Lots of Whacking | Win a game of Alien Abortion in the strip club.
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| Natural Disaster 3x | Kill 3 aliens at once.
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| Nobody Likes a Whiner | Knock out the talent at the talk show.
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| Noms | Eat 10 pieces of food during the SP campaign.
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| Not Bad for a Human | Defeat the Alien Queen.
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| Nuclear Devastation | Kill 250 aliens.
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| Octacide | Defeat the Octaking.
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| On the Noggin' | Kill 30 aliens with headshots.
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| One-Eyed Freak | Defeat the Cycloid.
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| Party Animal | Drink all of the beers in the strip club.
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| Pescaphobe | Kill all of the catfish in the underwater level.
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| Piece of Cake | Complete the SP campaign on Easy Difficulty.
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| Pit Champion | Defeat the Battlelord in Las Vegas.
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| Road Rage | Kill 15 aliens with the monster truck.
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| Special Thanks | Watch the credits all the way through.
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| Sticky Bomb Like You! | Put a Trip Mine on a live alien.
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| Substance Abuser | Drink beer while on steroids or vice-versa in SP.
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| Sunday, Black Sunday | Shoot down the blimp above the stadium.
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| Tosser... in the Literal Sense | Kill 10 aliens with tossed objects.
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| Trapper | Kill 10 aliens with trip mines.
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| Turd Burglar | Find and steal a piece of poo.
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| Achievement | How to unlock
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|---|
| Another Piece of Cake | Beat the DLC campaign on Easy Difficulty.
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| Bloody Red Rover | Kill 30 enemies with the moon rover.
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| Bubble Buster | Kill 10 expanded enemies with melee attacks.
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| Come Get a Little More | Beat the DLC campaign on Hard Difficulty.
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| Damn, I'm REALLY Good | Beat the DLC campaign on Expert Difficulty.
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| Heart to Heart | Finish Doctor Proton.
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| Hedonist, not Misogynist | Discover and reject the video game that lets you slap women.
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| I Am All That Is Man - Again! | Discover all Ego cap rewards in the DLC campaign.
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| Let's Rock Out | Beat the DLC campaign on Normal Difficulty.
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| Passive Aggressive | Let 20 enemies die by someone else's hand.
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| Scientits | Earn a 1,000,000 pinball score on the Scientits pinball machine.
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| Threesome | Kill 3 enemies within 3 seconds with the Impregnader.
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