| Achievement | How to unlock
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| Advanced Research | Complete a game in Stage 2.
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| Brain Storm | Have four Brains.
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| Bullet Time | Complete a game with Hydra (Stage 1 or above)
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| Cavalry | Install three Horns in a Brain.
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| Collector | Pick up 2000 Cells.
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| Conquerer | Defeat 5000 Monsters.
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| Economist | Complete a game with Wealth (Stage 1 or above)
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| General | Link three different types of Offspring.
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| Heartquake | Defeat a Boss while you have only 1 HP.
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| Imprisonment | Defeat a Boss.
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| Last Stand | Defeat 20000 Monsters.
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| Leadership | Complete a game with Queen (Stage 1 or above)
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| Legendary | Upgrade three different projects to the maximum level in Culture Room.
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| Light Speed | Complete a game with Rhinoceros (Stage 1 or above)
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| Long Journey | Complete Wave 35 in Endless Mode.
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| Mad Scientist | Complete games with ten different Prototypes
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| Masterpiece | Complete Stage 5 with three different Prototypes.
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| Nature Law | Complete a game with Fate (Stage 1 or above)
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| One with nothing | Complete a game with only one brain (Stage 1 or above)
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| Pacifism | Complete a Wave without killing any monster.
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| Peace | Complete a game with Cuckoo (Stage 1 or above)
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| Perfect Research | Complete a game in Stage 5.
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| Photosynthesis | Complete a game with Nature (Stage 1 or above)
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| Poverty | Complete a game with Squander (Stage 1 or above)
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| Research Complete | Complete a game in Stage 1.
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| Rookie | Complete a game with Stomy (Stage 1 or above)
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| Ruthless | Complete a game with Hunk (Stage 1 or above)
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| Savage Strike | Link Limbs to four different Brains.
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| Slayer | Defeat 50000 Monsters.
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| Terminator | Link ten Organs to a Brain.
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| Torment | Link a Belly and a Poison Bag to the same Brain.
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| Transcendency | Complete a game in Stage 3.
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| Ultimate Research | Complete a game in Stage 4.
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| Unflinching | Have eight HP.
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| Universe | Complete a game with Harmony (Stage 1 or above)
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| Versatility | Complete games with three different Prototypes
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| Wheel of Life | Complete Wave 25 in Endless Mode.
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| Wingspan | Defeat a Boss while you are buffed by Wings.
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| Wisdom | Complete a game with Genius (Stage 1 or above)
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